(R)evolution of Viruses: Introduction to biothermodynamics of viruses

被引:0
作者
Popovic, Marko E. [1 ]
Tadic, Vojin [2 ]
Popovic, Marta [3 ]
机构
[1] Univ Belgrade, Inst Chem Technol & Met, Njegoseva 12, Belgrade 11000, Serbia
[2] Min & Met Inst, Dept Expt Testing Precious Met, Zeleni bulevar 35, Bor 19210, Serbia
[3] Univ Belgrade, Fac Biol, Studentski Trg 16, Belgrade 11000, Serbia
关键词
Mechanistic model; Virus-host interaction; SARS-CoV-2; Virus; Virus lifecycle; Pathogenicity; Infectivity; STANDARD GIBBS ENERGY; ISOTHERMAL TITRATION CALORIMETRY; SURFACE-PLASMON RESONANCE; THERMODYNAMIC PROPERTIES; SUPRAMOLECULAR ARCHITECTURE; SACCHAROMYCES-CEREVISIAE; ORGANIC-SUBSTANCES; COXSACKIEVIRUS B3; BINDING-AFFINITY; ABSOLUTE ENTROPY;
D O I
10.1016/j.virol.2024.110319
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
As of 26 April 2024, the International Committee on Taxonomy of Viruses has registered 14690 virus species. Of these, only several dozen have been chemically and thermodynamically characterized. Every virus species is characterized by a specific empirical formula and thermodynamic properties - enthalpy, entropy and Gibbs energy. These physical properties are used in a mechanistic model of virus-host interactions at the cell membrane and in the cytoplasm. This review article presents empirical formulas and Gibbs energies for all major variants of SARS-CoV-2. This article also reports and suggests a mechanistic model of evolutionary changes, with the example of time evolution of SARS-CoV-2 from 2019 to 2024.
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页数:18
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