Declining Prevalence of Human Papillomavirus Co-Infections Among Young Japanese Women With Cervical Cancer and Its Precursors

被引：0

作者：

Yoshiizumi, Eri ^{[1
]}

Onuki, Mamiko ^{[1
]}

Kukimoto, Iwao ^{[2
]}

Takahashi, Fumiaki ^{[3
]}

Matsui, Tomoya ^{[4
]}

Hamasaki, Kyoko ^{[5
]}

Kanao, Hiroyuki ^{[6
]}

Nio, Ai ^{[7
]}

Yahata, Hideaki ^{[8
]}

Goda, Mayuko ^{[9
]}

Yokoyama, Takanori ^{[10
]}

Hisa, Tsuyoshi ^{[11
]}

Tasaki, Kazuto ^{[12
]}

Tenjimbayashi, Yuri ^{[13
]}

Saji, Haruya ^{[14
]}

Kudaka, Wataru ^{[15
]}

Takei, Yuji ^{[16
]}

Shigeta, Shogo ^{[17
]}

Motohara, Takeshi ^{[18
]}

Matsumiya, Hiroko ^{[19
,20
]}

Nakamura, Keiichiro ^{[21
]}

Yoshida, Hiroyuki ^{[22
]}

Ishikawa, Mitsuya ^{[23
]}

Hamanishi, Junzo ^{[24
]}

Nakai, Hidekatsu ^{[25
]}

Mori-Uchino, Mayuyo ^{[26
]}

Hirashima, Yasuyuki ^{[27
]}

Sekizawa, Akihiko ^{[1
]}

Yoshikawa, Hiroyuki ^{[13
]}

Yaegashi, Nobuo ^{[17
]}

Matsumoto, Koji ^{[1
]}

机构：

[1] Showa Univ, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan

[2] Natl Inst Infect Dis, Pathogen Genom Ctr, Tokyo, Japan

[3] Iwate Med Univ, Dept Informat Sci, Div Med Engn, Yahaba, Japan

[4] Keio Univ, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan

[5] Hyogo Canc Ctr, Gynecol Oncol, Akashi, Japan

[6] Canc Inst Hosp, Dept Gynecol, Tokyo, Japan

[7] NHO Kyushu Canc Ctr, Gynecol Serv, Fukuoka, Japan

[8] Kyushu Univ, Grad Sch Med Sci, Dept Obstet & Gynecol, Fukuoka, Japan

[9] SAITAMA CANC CTR, DEPT GYNECOL, SAITAMA, Japan

[10] NHO Shikoku Canc Ctr, Dept Gynecol Oncol, Matsuyama, Japan

[11] Osaka Int Canc Inst, Dept Gynecol, Osaka, Japan

[12] Kurume Univ, Sch Med, Dept Obstet & Gynecol, Kurume, Japan

[13] Univ Tsukuba, Fac Med, Dept Obstet & Gynecol, Tsukuba, Japan

[14] Kanagawa Canc Ctr, Dept Gynecol, Yokohama, Kanagawa, Japan

[15] Univ Ryukyus, Grad Sch Med, Dept Obstet & Gynecol, Ryukyus, Okinawa, Japan

[16] Jichi Med Univ, Dept Obstet & Gynecol, Tochigi, Japan

[17] Tohoku Univ, Grad Sch Med, Dept Obstet & Gynecol, Sendai, Japan

[18] Kumamoto Univ, Fac Life Sci, Dept Obstet & Gynecol, Kumamoto, Japan

[19] Hokkaido Univ, Grad Sch Med, Dept Obstet & Gynecol, Sapporo, Japan

[20] Fac Med, Sapporo, Japan

[21] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Obstet & Gynecol, Okayama, Japan

[22] Saitama Med Univ, Int Med Ctr, Dept Gynecol Oncol, Saitama, Japan

[23] Natl Canc Ctr, Dept Gynecol, Tokyo, Japan

[24] Kyoto Univ, Grad Sch Med, Dept Gynecol & Obstet, Kyoto, Japan

[25] Kindai Univ, Fac Med, Dept Obstet & Gynecol, Osaka, Japan

[26] Univ Tokyo, Grad Sch Med, Dept Obstet & Gynecol, Tokyo, Japan

[27] Shizuoka Canc Ctr Hosp, Div Gynecol, Shizuoka, Japan

来源：

JOURNAL OF MEDICAL VIROLOGY | 2024年 / 96卷 / 12期

基金：

日本学术振兴会;

关键词：

cervical cancer; cervical intraepithelial neoplasia; co-infection; human papillomavirus; vaccination; CHLAMYDIA-TRACHOMATIS; POOLED ANALYSIS; MULTIPLE TYPES; INFECTION; RISK; HERPES; NEOPLASIA; PROFILE; IMPACT; AGE;

D O I：

10.1002/jmv.70096

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Co-infections with human papillomavirus (HPV) of multiple genotypes mainly occur due to increased sexual activity. To address the prevalence and trend of HPV co-infections in Japan, HPV-type-specific data from Japanese women (n = 8128) aged < 40 years and newly diagnosed with cervical abnormalities at 24 hospitals between 2012 and 2023 were analyzed. These included cervical intraepithelial neoplasia grade 1/2 (CIN1/2, n = 2745), CIN3/adenocarcinoma in situ (AIS) (n = 3953), and invasive cervical cancer (ICC, n = 1430). For women enrolled in this study since 2019, information on sexual behaviors was collected via a self-administered questionnaire. Time-trend analyses by disease category showed significant declines in the prevalence of multiple HPV infections in CIN1/2 (49.1%-38.3%, p(trend) = 0.0004), CIN3/AIS (44.7%-31.5%, p(trend) = 0.0002), and ICC (26.7%-10.5%, p(trend) < 0.0001) during the last decade. When these data were analyzed separately for women aged 20-29 and 30-39 years, similar declining trends were observed in each disease category. Using data from 2111 women for whom information on sexual history was available, the number of sexual partners was strongly associated with increased multiple HPV infections (p < 0.0001). In conclusion, the declining prevalence of HPV co-infections in cervical cancer and its precursors may reflect a decrease in sexual activity among Japanese women of reproductive age.

引用

页数：8

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