Peeling the onion: how complex is the artemisinin resistance genetic trait of malaria parasites?

被引：2

作者：

Kucharski, Michal ^{[1
,2
]}

Nayak, Sourav ^{[1
]}

Gendrot, Mathieu ^{[1
]}

Dondorp, Arjen M. ^{[3
,4
,5
]}

Bozdech, Zbynek ^{[1
,6
]}

机构：

[1] Nanyang Technol Univ, Sch Biol Sci, Singapore, Singapore

[2] Univ Amsterdam, Amsterdam UMC, Amsterdam Inst Global Hlth & Dev, Dept Global Hlth, Amsterdam, Netherlands

[3] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand

[4] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England

[5] Univ Amsterdam, Ctr Trop Med & Travel Med, Acad Med Ctr, Dept Infect Dis, Amsterdam, Netherlands

[6] Univ Oxford, Nuffield Dept Med, Oxford, England

来源：

TRENDS IN PARASITOLOGY | 2024年 / 40卷 / 11期

基金：

英国医学研究理事会;

关键词：

PLASMODIUM-FALCIPARUM RESISTANCE; MECHANISMS; HETEROGENEITY; POLYMORPHISM; PIPERAQUINE; POPULATION; TOLERANCE; EMERGENCE; SURVIVAL; ORIGINS;

D O I：

10.1016/j.pt.2024.09.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The genetics of Plasmodium as an intracellular, mostly haploid, sexually reproducing, eukaryotic organism with a complex life cycle, presents unprecedented challenges in studying drug resistance. This article summarizes current knowledge on the genetic basis of artemisinin resistance (AR) - a main component of current drug therapies for falciparum malaria. Although centered on nonsynonymous single-nucleotide polymorphisms (nsSNPs), we describe multifaceted resistance mechanisms as part of a complex, cumulative genetic trait that involves regulation of expression by a wide array of polymorphisms in noncoding regions. These geand population dynamics, ultimately influencing the emergence and spread of the resistance.

引用

页码：970 / 986

页数：17