Peeling the onion: how complex is the artemisinin resistance genetic trait of malaria parasites?

被引：1
|
作者：
Kucharski, Michal [1 ,2 ]
Nayak, Sourav [1 ]
Gendrot, Mathieu [1 ]
Dondorp, Arjen M. [3 ,4 ,5 ]
Bozdech, Zbynek [1 ,6 ]
机构：
[1] Nanyang Technol Univ, Sch Biol Sci, Singapore, Singapore
[2] Univ Amsterdam, Amsterdam UMC, Amsterdam Inst Global Hlth & Dev, Dept Global Hlth, Amsterdam, Netherlands
[3] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand
[4] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England
[5] Univ Amsterdam, Ctr Trop Med & Travel Med, Acad Med Ctr, Dept Infect Dis, Amsterdam, Netherlands
[6] Univ Oxford, Nuffield Dept Med, Oxford, England
来源：
TRENDS IN PARASITOLOGY | 2024年 / 40卷 / 11期
基金：
英国医学研究理事会;
关键词：
PLASMODIUM-FALCIPARUM RESISTANCE; MECHANISMS; HETEROGENEITY; POLYMORPHISM; PIPERAQUINE; POPULATION; TOLERANCE; EMERGENCE; SURVIVAL; ORIGINS;
D O I：
10.1016/j.pt.2024.09.002
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The genetics of Plasmodium as an intracellular, mostly haploid, sexually reproducing, eukaryotic organism with a complex life cycle, presents unprecedented challenges in studying drug resistance. This article summarizes current knowledge on the genetic basis of artemisinin resistance (AR) - a main component of current drug therapies for falciparum malaria. Although centered on nonsynonymous single-nucleotide polymorphisms (nsSNPs), we describe multifaceted resistance mechanisms as part of a complex, cumulative genetic trait that involves regulation of expression by a wide array of polymorphisms in noncoding regions. These geand population dynamics, ultimately influencing the emergence and spread of the resistance.
引用
收藏
页码：970 / 986
页数：17
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