Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys
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Zhou, Ming
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Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Zhou, Ming
[1
]
Shi, Zhuo-Xing
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Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Shi, Zhuo-Xing
[1
]
Liu, Zhong
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Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Liu, Zhong
[1
]
Ke, Shu-Rui
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Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Ke, Shu-Rui
[1
]
Wang, Chao-Yang
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Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Wang, Chao-Yang
[1
]
Liang, Xiao-Lin
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Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Liang, Xiao-Lin
[1
]
Hu, Qiu-Ling
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Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Hu, Qiu-Ling
[1
]
Zhang, Qi-Kai
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Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Zhang, Qi-Kai
[1
]
Wang, Dong-Liang
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Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Wang, Dong-Liang
[1
]
Sun, Li
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Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Sun, Li
[1
]
Lin, Yu-Heng
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Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Lin, Yu-Heng
[1
]
Dai, Qi
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机构:
Zhejiang Sci Tech Univ, Coll Life Sci & Med, Hangzhou, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Dai, Qi
[2
]
Zheng, Ying-Feng
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机构:
Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Chinese Acad Med Sci, Res Unit Ocular Dev & Regenerat, Beijing 100085, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
Zheng, Ying-Feng
[1
,3
]
机构:
[1] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China
[2] Zhejiang Sci Tech Univ, Coll Life Sci & Med, Hangzhou, Peoples R China
[3] Chinese Acad Med Sci, Res Unit Ocular Dev & Regenerat, Beijing 100085, Peoples R China
P URPOSE . Corneal wounding healing is critical for maintaining clear vision, however, a complete understanding of its dynamic regulatory mechanisms remains elusive. Here, we used single-cell RNA sequencing (scRNA-seq) to analyze the cellular activities and transcriptional changes of corneal limbal epithelial cells at different stages after wound healing in cynomolgus monkeys, which exhibit a closer transcriptomic similarity to humans. M ETHODS . Corneal limbal tissues were collected during uninjured, 1-day and 3-day healing stages, dissociated into single cells, and subjected to scRNA-seq using the 10x x Genomics platform. Cell types were clustered by graph-based visualization methods and unbiased computational analysis. Additionally, cell migration assays and immunofluorescent staining were performed on cultured human corneal epithelial cells. R ESULTS . We characterized nine cell clusters by scRNA-seq analysis of the cynomolgus monkey corneal epithelium. By comparing heterogeneous transcriptional changes in major cell types during corneal healing, we highlighted the importance of limbal epithelial cells (LEPCs) and basal epithelial cells (BEPCs) in extracellular matrix (ECM) formation and wound healing, as well as suprabasal epithelial cells (SEPCs) in epithelial differentiation during the healing processes. We further identified five different sub-clusters in LEPC, including the transit amplifying cell (TAC) sub-cluster that promotes early healing through the activation of thrombospondin-1 ( THBS1 ) expression. C ONCLUSIONS . Our study represents the first comprehensive exploration of the detailed transcriptome profile of individual corneal cells during the wound healing process in nonhuman primates. We demonstrate the intricate mechanisms involved in corneal healing and provide a promising avenue for potential therapies in corneal wound healing.
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[1]
Agrawal Vinay B, 2003, Indian J Ophthalmol, V51, P5
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Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, IsraelTechnion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, Israel
Amitai-Lange, Aya
Altshuler, Anna
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Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, IsraelTechnion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, Israel
Altshuler, Anna
Bubley, Jeffrey
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Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, IsraelTechnion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, Israel
Bubley, Jeffrey
Dbayat, Noora
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Hillel Yaffe Med Ctr, Dept Ophthalmol, Hadera, IsraelTechnion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, Israel
Dbayat, Noora
Tiosano, Beatrice
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Hillel Yaffe Med Ctr, Dept Ophthalmol, Hadera, IsraelTechnion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, Israel
Tiosano, Beatrice
Shalom-Feuerstein, Ruby
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Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, IsraelTechnion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, Israel
机构:
Univ Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USAUniv Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA
Barrientez, Brayden
Nicholas, Sarah E.
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Univ Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USAUniv Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA
Nicholas, Sarah E.
Whelchel, Amy
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Univ Oklahoma, Dept Physiol, Hlth Sci Ctr, Oklahoma City, OK 73104 USAUniv Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA
Whelchel, Amy
Sharif, Rabab
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h-index: 0
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Univ Oklahoma, Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK 73104 USAUniv Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA
Sharif, Rabab
Hjortdal, Jesper
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h-index: 0
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Aarhus Univ Hosp, Dept Ophthalmol, Aarhus, DenmarkUniv Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA
机构:
Univ Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USA
Gonzalez, Sheyla
Roberts, JoAnn S.
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Univ Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USA
Roberts, JoAnn S.
Robertson, Sarah Y. T.
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Univ Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USA
Robertson, Sarah Y. T.
Ruiz, Maxime
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Univ Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USA
Ruiz, Maxime
Zheng, Jie
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Univ Calif Los Angeles, Stein Eye Inst, Div Basic Sci, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USA
Zheng, Jie
Deng, Sophie X.
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Univ Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USA
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Collin, Joseph
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Queen, Rachel
Zerti, Darin
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Univ Aquila, Microscopy Ctr, Laquila, Italy
Univ Aquila, Dept Appl Clin Sci & Biotechnol, Laquila, ItalyNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Zerti, Darin
Bojic, Sanja
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Bojic, Sanja
Dorgau, Birthe
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Dorgau, Birthe
Moyse, Nicky
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Newcastle Univ, Newcastle Cellular Therapies Facil, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Moyse, Nicky
Molina, Marina Moya
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Molina, Marina Moya
Yang, Chunbo
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Yang, Chunbo
Dey, Sunanda
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Technion Israel Inst Technol, Dept Genet & Dev Biol, Ruth & Bruce Rappaport Fac Med, Haifa, IsraelNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Dey, Sunanda
Reynolds, Gary
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Reynolds, Gary
Hussain, Rafiqul
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Hussain, Rafiqul
Coxhead, Jonathan M.
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Coxhead, Jonathan M.
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Lisgo, Steven
Henderson, Deborah
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Henderson, Deborah
Joseph, Agatha
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NHS Blood & Transplant Tissue & Eye Serv, Liverpool, Merseyside, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Joseph, Agatha
Rooney, Paul
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NHS Blood & Transplant Tissue & Eye Serv, Liverpool, Merseyside, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Rooney, Paul
Ghosh, Saurabh
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South Tyneside & Sunderland NHS Fdn Trust, Sunderland Eye Infirm, Sunderland, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Ghosh, Saurabh
Clarke, Lucy
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Royal Victoria Infirm, UK Dept Ophthalmol, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Clarke, Lucy
Connon, Che
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Connon, Che
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Haniffa, Muzlifah
Figueiredo, Francisco
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Royal Victoria Infirm, UK Dept Ophthalmol, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Figueiredo, Francisco
Armstrong, Lyle
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Armstrong, Lyle
Lako, Majlinda
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
机构:
Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, IsraelTechnion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, Israel
Amitai-Lange, Aya
Altshuler, Anna
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h-index: 0
机构:
Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, IsraelTechnion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, Israel
Altshuler, Anna
Bubley, Jeffrey
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Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, IsraelTechnion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, Israel
Bubley, Jeffrey
Dbayat, Noora
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h-index: 0
机构:
Hillel Yaffe Med Ctr, Dept Ophthalmol, Hadera, IsraelTechnion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, Israel
Dbayat, Noora
Tiosano, Beatrice
论文数: 0引用数: 0
h-index: 0
机构:
Hillel Yaffe Med Ctr, Dept Ophthalmol, Hadera, IsraelTechnion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, Israel
Tiosano, Beatrice
Shalom-Feuerstein, Ruby
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h-index: 0
机构:
Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, IsraelTechnion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Dept Genet & Dev Biol, IL-31096 Haifa, Israel
机构:
Univ Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USAUniv Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA
Barrientez, Brayden
Nicholas, Sarah E.
论文数: 0引用数: 0
h-index: 0
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Univ Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USAUniv Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA
Nicholas, Sarah E.
Whelchel, Amy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oklahoma, Dept Physiol, Hlth Sci Ctr, Oklahoma City, OK 73104 USAUniv Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA
Whelchel, Amy
Sharif, Rabab
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oklahoma, Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK 73104 USAUniv Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA
Sharif, Rabab
Hjortdal, Jesper
论文数: 0引用数: 0
h-index: 0
机构:
Aarhus Univ Hosp, Dept Ophthalmol, Aarhus, DenmarkUniv Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA
机构:
Univ Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USA
Gonzalez, Sheyla
Roberts, JoAnn S.
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h-index: 0
机构:
Univ Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USA
Roberts, JoAnn S.
Robertson, Sarah Y. T.
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h-index: 0
机构:
Univ Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USA
Robertson, Sarah Y. T.
Ruiz, Maxime
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h-index: 0
机构:
Univ Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USA
Ruiz, Maxime
Zheng, Jie
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h-index: 0
机构:
Univ Calif Los Angeles, Stein Eye Inst, Div Basic Sci, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USA
Zheng, Jie
Deng, Sophie X.
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h-index: 0
机构:
Univ Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stein Eye Inst, Cornea Div, Los Angeles, CA 90095 USA
机构:
Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Collin, Joseph
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Queen, Rachel
Zerti, Darin
论文数: 0引用数: 0
h-index: 0
机构:
Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Univ Aquila, Microscopy Ctr, Laquila, Italy
Univ Aquila, Dept Appl Clin Sci & Biotechnol, Laquila, ItalyNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Zerti, Darin
Bojic, Sanja
论文数: 0引用数: 0
h-index: 0
机构:
Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Bojic, Sanja
Dorgau, Birthe
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h-index: 0
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Dorgau, Birthe
Moyse, Nicky
论文数: 0引用数: 0
h-index: 0
机构:
Newcastle Univ, Newcastle Cellular Therapies Facil, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Moyse, Nicky
Molina, Marina Moya
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h-index: 0
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Molina, Marina Moya
Yang, Chunbo
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h-index: 0
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Yang, Chunbo
Dey, Sunanda
论文数: 0引用数: 0
h-index: 0
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Technion Israel Inst Technol, Dept Genet & Dev Biol, Ruth & Bruce Rappaport Fac Med, Haifa, IsraelNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Dey, Sunanda
Reynolds, Gary
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h-index: 0
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Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Reynolds, Gary
Hussain, Rafiqul
论文数: 0引用数: 0
h-index: 0
机构:
Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Hussain, Rafiqul
Coxhead, Jonathan M.
论文数: 0引用数: 0
h-index: 0
机构:
Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Coxhead, Jonathan M.
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Lisgo, Steven
Henderson, Deborah
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h-index: 0
机构:
Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Henderson, Deborah
Joseph, Agatha
论文数: 0引用数: 0
h-index: 0
机构:
NHS Blood & Transplant Tissue & Eye Serv, Liverpool, Merseyside, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Joseph, Agatha
Rooney, Paul
论文数: 0引用数: 0
h-index: 0
机构:
NHS Blood & Transplant Tissue & Eye Serv, Liverpool, Merseyside, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Rooney, Paul
Ghosh, Saurabh
论文数: 0引用数: 0
h-index: 0
机构:
South Tyneside & Sunderland NHS Fdn Trust, Sunderland Eye Infirm, Sunderland, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Ghosh, Saurabh
Clarke, Lucy
论文数: 0引用数: 0
h-index: 0
机构:
Royal Victoria Infirm, UK Dept Ophthalmol, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Clarke, Lucy
Connon, Che
论文数: 0引用数: 0
h-index: 0
机构:
Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Connon, Che
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Haniffa, Muzlifah
Figueiredo, Francisco
论文数: 0引用数: 0
h-index: 0
机构:
Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Royal Victoria Infirm, UK Dept Ophthalmol, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Figueiredo, Francisco
Armstrong, Lyle
论文数: 0引用数: 0
h-index: 0
机构:
Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Armstrong, Lyle
Lako, Majlinda
论文数: 0引用数: 0
h-index: 0
机构:
Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England