Mycobacterium abscessus Complex Infections Among Lung Transplant Recipients: A Multicenter Retrospective Cohort Study in Canada

被引：0

作者：

Bitterman, Roni ^{[1
]}

Soualhine, Hafid ^{[2
,3
]}

Akochy, Pierre-Marie ^{[4
]}

Poirier, Charles ^{[5
]}

Ferraro, Pasquale ^{[6
]}

Kabbani, Dima ^{[7
]}

Hirji, Alim ^{[8
]}

Tyrrell, Gregory ^{[9
]}

Bergeron, Celine ^{[10
]}

Levy, Robert D. ^{[10
]}

Wright, Alissa ^{[11
]}

Leung, Victor ^{[12
]}

Singer, Lianne G. ^{[13
]}

Chaparro, Cecilia ^{[13
]}

Keshavjee, Shaf ^{[14
]}

Richard-Greenblatt, Melissa ^{[15
,16
]}

Husain, Shahid ^{[1
]}

Luong, Me-Linh ^{[17
]}

机构：

[1] Univ Hlth Network, Div Infect Dis, Multiorgan Transplant Program, Toronto, ON, Canada

[2] Publ Hlth Agcy Canada, Natl Reference Ctr Mycobacteriol, Natl Microbiol Lab, Winnipeg, MB, Canada

[3] Univ Manitoba, Max Rady Coll Med, Dept Med Microbiol & Infect Dis, Winnipeg, MB, Canada

[4] LSPQ Inst Natl St Publ Quebec, Ste Anne De Bellevue, PQ H2P 1E2, Canada

[5] CHU Montreal, Lung Transplant Program, Montreal, PQ, Canada

[6] CHU Montreal, Dept Surg, Div Vasc Surg, Montreal, PQ, Canada

[7] Univ Alberta Hosp, Dept Med, Div Infect Dis, Edmonton, AB, Canada

[8] Univ Alberta, Univ Alberta Hosp, Edmonton, AB, Canada

[9] Mackenzie Hlth Sci Ctr, Dept Lab Med & Pathol, Div Diagnost & Appl Microbiol, Edmonton, AB, Canada

[10] Univ British Columbia, Vancouver Gen Hosp, Lung Transplantat Program, Div Resp Med, Vancouver, BC, Canada

[11] Vancouver Gen Hosp, Dept Med, Div Infect Dis, Vancouver, BC, Canada

[12] Providence Hlth Care, Dept Med Microbiol, Seattle, BC, Canada

[13] Univ Hlth Network, Toronto Lung Transplant Program, Div Respirol, Toronto, ON, Canada

[14] Univ Hlth Network, Toronto Lung Transplant Program, Div Thorac Surg, Toronto, ON, Canada

[15] Publ Hlth Ontario, Toronto, ON, Canada

[16] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[17] CHU Montreal, Dept Med Neurol, Montreal, PQ, Canada

来源：

TRANSPLANT INFECTIOUS DISEASE | 2025年

关键词：

lung transplantation; <italic>Mycobacterium abscessus</italic>; nontuberculous mycobacteria; CYSTIC-FIBROSIS; PULMONARY INFECTION; MASSILIENSE; OUTCOMES; DISEASE; PREVENTION; PATIENT; GENE;

D O I：

10.1111/tid.70003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BackgroundMycobacterium abscessus complex is known to cause life-threatening disease in lung transplantation (LT) recipients (LTRs). Therefore, many centers consider the presence of M. abscessus as a relative contraindication to LT.MethodsWe conducted a multicenter retrospective cohort study including all 4 LT centers in Canada. All LTRs transplanted in 2006-2016 with at least one respiratory sample positive for M. abscessus prior or posttransplantation were included. Pulmonary disease was defined using the American Thoracic Society criteria. Minimal follow-up duration was 5 years after transplantation.ResultsAmong 2181 LTRs across Canada, 14 had M. abscessus disease after LT (incidence rate 1.1/1000 transplant-years) and 6 had pulmonary colonization (incidence rate 0.5/1000 transplant-years). Fifteen patients had M. abscessus cultured before LT. Among those with pretransplant M. abscessus, 53% (8/15) developed M. abscessus infection posttransplant (6 disease, 2 colonization). Posttransplant disease was less frequent among those with microbiologic eradication before transplant (0% vs. 85.7%, p = 0.001). LTRs with pretransplant M. abscessus had comparable survival to those without M. abscessus (log rank p = 0.37). Among patients with pretransplant infection, mortality was higher in those who did not achieve microbiological eradication before transplantation (57.1% vs. 0%, p = 0.03) and those who developed disease after transplantation (66.7% vs. 0%, p = 0.01).ConclusionsM. abscessus is an uncommon cause of infection among LTRs. Survival among those with pretransplant M. abscessus infection was similar to that observed in noninfected LTRs. However, lack of eradication before transplantation was associated with higher posttransplant disease and mortality.

引用

页数：10

共 39 条

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