Antioxidant and antiplatelet effect of nanodispersions with conjugate of glutathione and lipoic acid

被引：0
|
作者：
Inshakova, Anna M. [1 ]
Shchelkonogov, Vasiliy A. [1 ,2 ]
Shastina, Natalya S. [1 ]
Chekanov, Andrey V. [2 ]
Baranova, Olga A. [2 ]
Sokolova, Margarita O. [3 ]
Ivanova, Anastasia K. [3 ]
Fedin, Anatoly I. [2 ]
Solov'eva, Ella Yu. [2 ]
机构：
[1] MIREA Russian Technol Univ, MV Lomonosov Inst Fine Chem Technol, Moscow 119571, Russia
[2] NI Pirogov Russian Natl Res Med Univ, Moscow 117997, Russia
[3] SM Kirov Mil Med Acad, St Petersburg 194044, Russia
来源：
MENDELEEV COMMUNICATIONS | 2024年 / 34卷 / 06期
关键词：
nanodispersions; lipoic acid; glutathione; neutrophils; OXIDATIVE STRESS; ESTERS;
D O I：
10.1016/j.mencom.2024.10.037
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
To increase the therapeutic effectiveness of antioxidants (lipoic acid and glutathione) and improve their transport to target cells, various methods of modifying its substances are used. In this work, the synthesis of an amide derivative of lipoic acid and glutathione (GSH-LA) is performed, and GSH-LA nanodispersions based on Pluronic F68 are obtained. The most pronounced antioxidant and antiplatelet effects are exhibited by nanoparticles containing GSH-LA at the maximum tested concentration.
引用
收藏
页码：887 / 889
页数：3
相关论文
共 50 条
  • [41] SYNERGISTIC ANTIOXIDANT ACTIVITY OF LIPOIC, FERULIC AND ELLAGIC ACID
    Chawla, Priyanka
    Gaur, Himanshu
    Tripathi, Mamta
    Tripathi, Mridula
    Agarwal, Babita
    Pandey, Archana
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2015, 6 (06): : 2551 - 2556
  • [42] α-Lipoic acid is ineffective as a topical antioxidant for photoprotection of skin
    Lin, JY
    Lin, FH
    Burch, JA
    Selim, MA
    Monteiro-Riviere, NA
    Grichnik, JM
    Pinnell, SR
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (05) : 996 - 998
  • [43] Antioxidant activities of dithiol alpha-lipoic acid
    Islam, M. T.
    BANGLADESH JOURNAL OF MEDICAL SCIENCE, 2009, 8 (03): : 46 - 51
  • [44] Antioxidant Effect of Caffeic Acid Derivatives on Sod and Glutathione Defective Yeasts
    E. R. Prudêncio
    C. M. Cardoso
    R. N. Castro
    C. J. Riger
    Applied Biochemistry and Microbiology, 2019, 55 : 264 - 269
  • [45] Antioxidant Effect of Caffeic Acid Derivatives on Sod and Glutathione Defective Yeasts
    Prudencio, E. R.
    Cardoso, C. M.
    Castro, R. N.
    Riger, C. J.
    APPLIED BIOCHEMISTRY AND MICROBIOLOGY, 2019, 55 (03) : 264 - 269
  • [46] Chromone-lipoic acid conjugate: Neuroprotective agent having acceptable butyrylcholinesterase inhibition, antioxidant and copper-chelation activities
    Jalili-Baleh, Leili
    Nadri, Hamid
    Forootanfar, Hamid
    Kucukkilinc, Tuba Tuylu
    Ayazgok, Beyza
    Sharifzadeh, Mohammad
    Rahimifard, Mahban
    Baeeri, Maryam
    Abdollahi, Mohammad
    Foroumadi, Alireza
    Khoobi, Mehdi
    DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 29 (01) : 23 - 38
  • [47] Synthesis, characterization and chemisorption on gold of a β-cyclodextrin-lipoic acid conjugate
    Carofiglio, T
    Fornasier, R
    Jicsinszky, L
    Tonellato, U
    Turco, C
    TETRAHEDRON LETTERS, 2001, 42 (31) : 5241 - 5244
  • [48] Grafting of 4-aminomethylbenzensulfonamide-lipoic acid conjugate on gold nanoparticles
    Stiti, M.
    Bouzit, H.
    Abdaoui, M.
    Winum, J. Y.
    MATERIAUX 2010, 2012, 28
  • [49] Metabolic Effects of γ-Linolenic Acid-α-Lipoic Acid Conjugate in Streptozotocin Diabetic Rats
    Khamaisi, Mogher
    Rudich, Assaf
    Beeri, Ido
    Pessler, Dorit
    Friger, Michael
    Gavrilov, Vladimir
    Tritschler, Hans
    Bashan, Nava
    ANTIOXIDANTS & REDOX SIGNALING, 1999, 1 (04) : 523 - 535
  • [50] Effect of lipoic acid on the activity of caspases and the characteristics of the immune and antioxidant statuses in rats with rheumatoid arthritis
    Kryl'skiy, E. D.
    Popova, T. N.
    Kirilova, E. M.
    Safonova, O. A.
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2016, 42 (04) : 389 - 396
12345