Antioxidant and antiplatelet effect of nanodispersions with conjugate of glutathione and lipoic acid

被引：0
|
作者：
Inshakova, Anna M. [1 ]
Shchelkonogov, Vasiliy A. [1 ,2 ]
Shastina, Natalya S. [1 ]
Chekanov, Andrey V. [2 ]
Baranova, Olga A. [2 ]
Sokolova, Margarita O. [3 ]
Ivanova, Anastasia K. [3 ]
Fedin, Anatoly I. [2 ]
Solov'eva, Ella Yu. [2 ]
机构：
[1] MIREA Russian Technol Univ, MV Lomonosov Inst Fine Chem Technol, Moscow 119571, Russia
[2] NI Pirogov Russian Natl Res Med Univ, Moscow 117997, Russia
[3] SM Kirov Mil Med Acad, St Petersburg 194044, Russia
来源：
MENDELEEV COMMUNICATIONS | 2024年 / 34卷 / 06期
关键词：
nanodispersions; lipoic acid; glutathione; neutrophils; OXIDATIVE STRESS; ESTERS;
D O I：
10.1016/j.mencom.2024.10.037
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
To increase the therapeutic effectiveness of antioxidants (lipoic acid and glutathione) and improve their transport to target cells, various methods of modifying its substances are used. In this work, the synthesis of an amide derivative of lipoic acid and glutathione (GSH-LA) is performed, and GSH-LA nanodispersions based on Pluronic F68 are obtained. The most pronounced antioxidant and antiplatelet effects are exhibited by nanoparticles containing GSH-LA at the maximum tested concentration.
引用
收藏
页码：887 / 889
页数：3
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