Alcohol impairs learning and timing of conditioned eyeblink responses

被引：0

作者：

Johansson, Fredrik ^{[1
]}

Rydberg, Vincent ^{[1
]}

Arn, Nils-Erik ^{[1
]}

Lundin, Johannes ^{[1
]}

Gornov, Artem ^{[1
]}

Winton, Robert ^{[1
]}

Madison, Guy ^{[2
]}

Hesslow, Germund ^{[1
]}

Rasmussen, Anders ^{[1
]}

机构：

[1] Lund Univ, Fac Med, Dept Expt Med Sci, Lund, Sweden

[2] Umea Univ, Dept Psychol, Umea, Sweden

来源：

BRAIN RESEARCH | 2025年 / 1854卷

基金：

瑞典研究理事会;

关键词：

Alcohol; Motor Ability; Motor Learning; Eyeblink Conditioning; Timing; Pharmacology; Cerebellum; ETHANOL; CEREBELLUM; INTOXICATION; INVOLVEMENT;

D O I：

10.1016/j.brainres.2025.149545

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alcohol impairs motor performance, but it remains unclear precisely why this is the case. Here, we examine the effects of alcohol intoxication on conditioned eyeblink responses, a form of classical conditioning dependent on the cerebellum. In experiment 1, the conditioned responses of 18 students before and after alcohol consumption up to 1 %o were compared against the performance of 26 non-drinking controls. In experiment 2, 17 students were tested repeatedly at increasing blood alcohol levels up to 1 %o. The results reveal a gradual decrease in both the percentage and timing of conditioned responses following alcohol consumption, with pronounced impairments emerging at blood alcohol content levels exceeding 0.5 %o. These findings are consistent with the idea that the motor deficits associated with alcohol consumption are linked to effects on the cerebellum.

引用

页数：6

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