Molecular mechanisms of Japanese encephalitis virus infection and advances in vaccine research

被引：0
作者：
Gong, Junyou [1 ]
Duan, Xianghan [2 ]
Ge, Zhaoming [1 ]
机构：
[1] Lanzhou Univ Second Hosp, Dept Neurol, Lanzhou 730000, Gansu, Peoples R China
[2] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou 510000, Guangdong, Peoples R China
来源：
MICROBIAL PATHOGENESIS | 2025年 / 201卷
关键词：
JEV; Encoded proteins; Infection; Replication; Vaccine; DENGUE VIRUS; PROTECTIVE IMMUNITY; NONSTRUCTURAL PROTEIN-1; CLINICAL-TRIALS; IMMUNOGENICITY; SAFETY; NS1; ENTRY; IDENTIFICATION; IMMUNIZATION;
D O I：
10.1016/j.micpath.2025.107397
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Japanese encephalitis (JE) is a central nervous system disease caused by the Japanese encephalitis virus (JEV), resulting in high morbidity and mortality, especially in Asia. This review summarizes the current understanding of the JEV infection cycle, including virus attachment and entry, genome replication, viral protein translation, and virus particle assembly and release. The roles of host factors and viral proteins in these processes are discussed. Furthermore, the latest advancements in JE vaccine research are emphasized, including the development of attenuated vaccine SA14-14-2, inactivated mouse brain-derived vaccine, inactivated cell culture vaccine, and chimeric attenuated vaccine. The efficacy and safety of these candidate vaccines and ongoing efforts to enhance their immunogenicity are also reviewed. A comprehensive understanding of the molecular mechanisms of JEV infection and advancements in vaccine research is crucial for the development of effective strategies for JE control and prevention.
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页数：8
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共 97 条
[81]  
Harrison J.J., Nguyen W., Morgan M.S., Tang B., Habarugira G., de Malmanche H., Freney M.E., Modhiran N., Watterson D., Cox A.L., Yan K., Yuen N.K.Y., Bowman D.H., Kirkland P.D., Bielefeldt-Ohmann H., Suhrbier A., Hall R.A., Rawle D.J., Hobson-Peters J., A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challenge, NPJ vaccines, 9, (2024)
[82]  
Plotkin S.A., Cadoz M., Meignier B., Meric C., Leroy O., Excler J.L., Tartaglia J., Paoletti E., Gonczol E., Chappuis G., The safety and use of canarypox vectored vaccines, Dev. Biol. Stand., 84, pp. 165-170, (1995)
[83]  
Kanesa-thasan N., Smucny J.J., Hoke C.H., Marks D.H., Konishi E., Kurane I., Tang D.B., Vaughn D.W., Mason P.W., Shope R.E., Safety and immunogenicity of NYVAC-JEV and ALVAC-JEV attenuated recombinant Japanese encephalitis virus-poxvirus vaccines in vaccinia-nonimmune and vaccinia-immune humans, Vaccine, 19, pp. 483-491, (2000)
[84]  
Lin Y.L., Chen L.K., Liao C.L., Yeh C.T., Ma S.H., Chen J.L., Huang Y.L., Chen S.S., Chiang H.Y., DNA immunization with Japanese encephalitis virus nonstructural protein NS1 elicits protective immunity in mice, J. Virol., 72, pp. 191-200, (1998)
[85]  
Gao N., Chen W., Zheng Q., Fan D.Y., Zhang J.L., Chen H., Gao G.F., Zhou D.S., An J., Co-expression of Japanese encephalitis virus prM-E-NS1 antigen with granulocyte-macrophage colony-stimulating factor enhances humoral and anti-virus immunity after DNA vaccination, Immunol. Lett., 129, pp. 23-31, (2010)
[86]  
Chen H., Gao N., Fan D., Wu J., Zhu J., Li J., Wang J., Chen Y., An J., Suppressive effects on the immune response and protective immunity to a JEV DNA vaccine by co-administration of a GM-CSF-expressing plasmid in mice, PLoS One, 7, (2012)
[87]  
Ahsan M.F., Gore M.M., Comparison of immune response generated against Japanese encephalitis virus envelope protein expressed by DNA vaccines under macrophage associated versus ubiquitous expression promoters, Virol. J., 8, (2011)
[88]  
Yao M., Ren X., Yin M., Chen H., Li X., Qian P., Nanoparticle vaccine based on the envelope protein domain III of Japanese encephalitis virus elicits robust protective immune responses in mice, Nanomedicine (London, England), 18, pp. 5-18, (2023)
[89]  
Zhao F., Zhai Y., Zhu J., Xiao P., Feng G., Enhancement of autophagy as a strategy for development of new DNA vaccine candidates against Japanese encephalitis, Vaccine, 37, pp. 5588-5595, (2019)
[90]  
Eslick G.D., Teutsch S.M., Elliott E.J., Japanese encephalitis virus: changing the clinical landscape of encephalitis in Australia, Med. J. Aust., 219, (2023)
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