Molecular mechanisms of Japanese encephalitis virus infection and advances in vaccine research

被引：0
作者：
Gong, Junyou [1 ]
Duan, Xianghan [2 ]
Ge, Zhaoming [1 ]
机构：
[1] Lanzhou Univ Second Hosp, Dept Neurol, Lanzhou 730000, Gansu, Peoples R China
[2] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou 510000, Guangdong, Peoples R China
来源：
MICROBIAL PATHOGENESIS | 2025年 / 201卷
关键词：
JEV; Encoded proteins; Infection; Replication; Vaccine; DENGUE VIRUS; PROTECTIVE IMMUNITY; NONSTRUCTURAL PROTEIN-1; CLINICAL-TRIALS; IMMUNOGENICITY; SAFETY; NS1; ENTRY; IDENTIFICATION; IMMUNIZATION;
D O I：
10.1016/j.micpath.2025.107397
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Japanese encephalitis (JE) is a central nervous system disease caused by the Japanese encephalitis virus (JEV), resulting in high morbidity and mortality, especially in Asia. This review summarizes the current understanding of the JEV infection cycle, including virus attachment and entry, genome replication, viral protein translation, and virus particle assembly and release. The roles of host factors and viral proteins in these processes are discussed. Furthermore, the latest advancements in JE vaccine research are emphasized, including the development of attenuated vaccine SA14-14-2, inactivated mouse brain-derived vaccine, inactivated cell culture vaccine, and chimeric attenuated vaccine. The efficacy and safety of these candidate vaccines and ongoing efforts to enhance their immunogenicity are also reviewed. A comprehensive understanding of the molecular mechanisms of JEV infection and advancements in vaccine research is crucial for the development of effective strategies for JE control and prevention.
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页数：8
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