Tailored Approaches in the Treatment of Patients With Colorectal Cancer Harboring Tropomyosin Receptor Kinase Fusion and Microsatellite Instability-High: A Case Report and Literature Review

被引：0

作者：

Kim, Samuel ^{[1
]}

Itani, Malak ^{[2
]}

Liu, Xiuli ^{[3
]}

Sun, Lulu ^{[3
]}

Krysiak, Kilannin ^{[3
]}

Fox, Nicole ^{[4
]}

Firwana, Belal ^{[5
]}

Al Diffalha, Sameer ^{[6
]}

Manne, Upender ^{[6
]}

Seeber, Andreas ^{[7
]}

Karl, Molly ^{[8
]}

Frank, Michele ^{[8
]}

Stubblefield, Hannah ^{[8
]}

Pedersen, Katrina ^{[8
]}

Lim, Kian-Huat ^{[8
]}

Abushukair, Hassan ^{[9
]}

Khushman, Moh'd ^{[8
]}

机构：

[1] Univ Missouri Kansas City, Kansas City, MO USA

[2] Washington Univ St Louis, Mallinckrodt Inst Radiol, St Louis, MO USA

[3] Washington Univ St Louis, Dept Pathol & Immunol, St Louis, MO USA

[4] Bayer Pharmaceut, Lead Med Sci Liaison Oncol, Whippany, NJ USA

[5] Missouri Baptist Med Ctr, Heartland Canc Res, Med Oncol, St Louis, MO USA

[6] Univ Alabama Birmingham, ONeal Comprehens Canc Ctr, Pathol, Birmingham, AL USA

[7] Comprehens Canc Ctr Innsbruck, Hematol Oncol, Innsbruck, Austria

[8] Washington Univ St Louis, Siteman Canc Ctr, Med Oncol, St Louis, MO 63130 USA

[9] Jordan Univ Sci & Technol, Irbid, Jordan

来源：

JCO PRECISION ONCOLOGY | 2025年 / 9卷

关键词：

POSITIVE SOLID TUMORS; TRK; LAROTRECTINIB;

D O I：

10.1200/PO.24.00305

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页数：6

共 22 条

[1] Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer [J].

Andre, T. ;

Shiu, K-K ;

Kim, T. W. ;

Jensen, B., V ;

Jensen, L. H. ;

Punt, C. ;

Smith, D. ;

Garcia-Carbonero, R. ;

Benavides, M. ;

Gibbs, P. ;

de la Fouchardiere, C. ;

Rivera, F. ;

Elez, E. ;

Bendell, J. ;

Le, D. T. ;

Yoshino, T. ;

Van Cutsem, E. ;

Yang, P. ;

Farooqui, M. Z. H. ;

Marinello, P. ;

Diaz, L. A., Jr. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (23) :2207-2218

[2] Neurotrophins and their receptors: A convergence point for many signalling pathways [J].

Chao, MV .

NATURE REVIEWS NEUROSCIENCE, 2003, 4 (04) :299-309

[3] Basket trial of TRK inhibitors demonstrates efficacy in TRK fusion-positive cancers [J].

Chen, Yu ;

Chi, Ping .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2018, 11

[4] NTRK gene rearrangements are highly enriched in MLH1/PMS2 deficient, BRAF wild-type colorectal carcinomas-a study of 4569 cases [J].

Chou, Angela ;

Fraser, Tamara ;

Ahadi, Mahsa ;

Fuchs, Talia ;

Sioson, Loretta ;

Clarkson, Adele ;

Sheen, Amy ;

Singh, Nisha ;

Corless, Christopher L. ;

Gill, Anthony J. .

MODERN PATHOLOGY, 2020, 33 (05) :924-932

[5] Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions [J].

Cocco, Emiliano ;

Benhamida, Jamal ;

Middha, Sumit ;

Zehir, Ahmet ;

Mullaney, Kerry ;

Shia, Jinru ;

Yaeger, Rona ;

Zhang, Liying ;

Wong, Donna ;

Villafania, Liliana ;

Nafa, Khedoudja ;

Scaltriti, Maurizio ;

Drilon, Alexander ;

Saltz, Leonard ;

Schram, Alison M. ;

Stadler, Zsofia K. ;

Hyman, David M. ;

Benayed, Ryma ;

Ladanyi, Marc ;

Hechtman, Jaclyn F. .

CANCER RESEARCH, 2019, 79 (06) :1047-1053

[6] Chromosomal rearrangements involving the NTRK1 gene in colorectal carcinoma [J].

Creancier, Laurent ;

Vandenberghe, Isabelle ;

Gomes, Bruno ;

Dejean, Caroline ;

Blanchet, Jean-Christophe ;

Meilleroux, Julie ;

Guimbaud, Rosine ;

Selves, Janick ;

Kruczynski, Anna .

CANCER LETTERS, 2015, 365 (01) :107-111

[7] Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials [J].

Doebele, Robert C. ;

Drilon, Alexander ;

Paz-Ares, Luis ;

Siena, Salvatore ;

Shaw, Alice T. ;

Farago, Anna F. ;

Blakely, Collin M. ;

Seto, Takashi ;

Cho, Byung Chul ;

Tosi, Diego ;

Besse, Benjamin ;

Chawla, Sant P. ;

Bazhenova, Lyudmila ;

Krauss, John C. ;

Chae, Young Kwang ;

Barve, Minal ;

Garrido-Laguna, Ignacio ;

Liu, Stephen V. ;

Conkling, Paul ;

John, Thomas ;

Fakih, Marwan ;

Sigal, Darren ;

Loong, Herbert H. ;

Buchschacher, Gary L., Jr. ;

Garrido, Pilar ;

Nieva, Jorge ;

Steuer, Conor ;

Overbeck, Tobias R. ;

Bowles, Daniel W. ;

Fox, Elizabeth ;

Riehl, Todd ;

Chow-Maneval, Edna ;

Simmons, Brian ;

Cui, Na ;

Johnson, Ann ;

Eng, Susan ;

Wilson, Timothy R. ;

Demetri, George D. .

LANCET ONCOLOGY, 2020, 21 (02) :271-282

[8] Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children [J].

Drilon, A. ;

Laetsch, T. W. ;

Kummar, S. ;

DuBois, S. G. ;

Lassen, U. N. ;

Demetri, G. D. ;

Nathenson, M. ;

Doebele, R. C. ;

Farago, A. F. ;

Pappo, A. S. ;

Turpin, B. ;

Dowlati, A. ;

Brose, M. S. ;

Mascarenhas, L. ;

Federman, N. ;

Berlin, J. ;

El-Deiry, W. S. ;

Baik, C. ;

Deeken, J. ;

Boni, V. ;

Nagasubramanian, R. ;

Taylor, M. ;

Rudzinski, E. R. ;

Meric-Bernstam, F. ;

Sohal, D. P. S. ;

Ma, P. C. ;

Raez, L. E. ;

Hechtman, J. F. ;

Benayed, R. ;

Ladanyi, M. ;

Tuch, B. B. ;

Ebata, K. ;

Cruickshank, S. ;

Ku, N. C. ;

Cox, M. C. ;

Hawkins, D. S. ;

Hong, D. S. ;

Hyman, D. M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (08) :731-739

[9] Molecular characterization of cancers with NTRK gene fusions [J].

Gatalica, Zoran ;

Xiu, Joanne ;

Swensen, Jeffrey ;

Vranic, Semir .

MODERN PATHOLOGY, 2019, 32 (01) :147-153

[10] Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions [J].

Hechtman, Jaclyn F. ;

Benayed, Ryma ;

Hyman, David M. ;

Drilon, Alexander ;

Zehir, Ahmet ;

Frosina, Denise ;

Arcila, Maria E. ;

Dogan, Snjezana ;

Klimstra, David S. ;

Ladanyi, Marc ;

Jungbluth, Achim A. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2017, 41 (11) :1547-1551

← 1 2 3 →