Diabetes and Atrial Fibrillation: Insight From Basic to Translational Science Into the Mechanisms and Management

被引：1

作者：

Kantharia, Bharat K. ^{[1
,2
]}

Tabary, Mohammadreza ^{[3
]}

Wu, Lingling ^{[4
]}

Wang, Xinyu ^{[3
]}

Narasimhan, Bharat ^{[5
]}

Linz, Dominik ^{[6
]}

Heijman, Jordi ^{[7
]}

Wehrens, Xander H. T. ^{[3
]}

机构：

[1] Cardiovasc & Heart Rhythm Consultants, New York, NY 10016 USA

[2] Icahn Sch Med Mt Sinai, New York, NY USA

[3] Cardiovasc Res Inst, Baylor Coll Med, Dept Integrat Physiol & Med, Houston, TX USA

[4] East Carolina Univ, Brody Sch Med, Greenville, NC USA

[5] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[6] Maastricht Univ, Med Ctr, Maastricht, Netherlands

[7] Med Univ Graz, Gottfried Schatz Res Ctr, Div Med Phys & Biophys, Graz, Austria

来源：

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY | 2025年

基金：

美国国家卫生研究院;

关键词：

antidiabetic drugs; atrial cardiomyopathy; atrial fibrillation; atriopathy; diabetes mellitus; fibrosis; inflammation; NF-KAPPA-B; OXIDATIVE STRESS; RISK-FACTORS; CATHETER ABLATION; SGLT2; INHIBITORS; MELLITUS; FIBROSIS; GLUCOSE; CARDIOMYOCYTES; DAPAGLIFLOZIN;

D O I：

10.1111/jce.16655

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In spite of significant progress made in the management in recent decades, atrial fibrillation (AF) continues to cause increased mortality and significant morbidities, including heart failure and stroke. Diabetes mellitus (DM) is an independent risk factor for AF, and adds risks to increased mortality and hospitalizations when present along with AF. The pathophysiology of AF related to DM is complex with many inter-related factors. Atrial cardiomyopathy (atriopathy) related to structural changes from subcellular abnormalities and fibrosis, coupled with cardiac mechanical dysfunction, abnormal ion expression, dysregulation of the renin-angiotensin-aldosterone system and the autonomic nervous system function, play crucial roles in genesis and progression of AF. In this review, we discuss insights from basic to translational science into the mechanisms and management related to AF associated with DM.

引用

页数：12

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