Dose-escalated Adaptive Radiotherapy for Bladder Cancer: Results of the Phase 2 RAIDER Randomised Controlled Trial

被引：2

作者：

Huddart, Robert ^{[1
,2
]}

Hafeez, Shaista ^{[1
,2
]}

Griffin, Clare ^{[1
]}

Choudhury, Ananya ^{[3
]}

Foroudi, Farshad ^{[4
]}

Syndikus, Isabel ^{[5
]}

Hindson, Benjamin ^{[6
]}

Webster, Amanda ^{[7
,8
]}

Mcnair, Helen ^{[1
,2
]}

Birtle, Alison ^{[9
,10
,11
]}

Varughese, Mohini ^{[12
]}

Henry, Ann ^{[13
,14
]}

Mclaren, Duncan ^{[15
]}

Parikh, Omi ^{[9
]}

Nikapota, Ashok ^{[16
]}

Tang, Colin ^{[17
]}

Patel, Emma ^{[18
]}

Miles, Elizabeth ^{[18
]}

Warren-Oseni, Karole ^{[1
,2
]}

Kron, Tomas ^{[19
]}

Hill, Courtney ^{[20
]}

Philipps, Lara ^{[1
]}

Vassallo-Bonner, Catalina ^{[1
]}

Cheung, Ka Ching ^{[1
]}

Gribble, Hannah ^{[1
]}

Lewis, Rebecca ^{[1
]}

Hall, Emma ^{[1
]}

机构：

[1] Inst Canc Res, Sutton, England

[2] Royal Marsden NHS Fdn Trust, Sutton, England

[3] Christie NHS Fdn Trust, Manchester, England

[4] Austin Hlth, Heidelberg, Vic, Australia

[5] Clatterbridge Canc Ctr, Bebington, England

[6] Christchurch Hosp, Canterbury Reg Canc & Haematol Serv, Christchurch, New Zealand

[7] Univ Coll Hosp, London, England

[8] Univ Coll Hosp, Univ Coll Hosp NHS Fdn Trust, London, England

[9] Lancashire Teaching Hosp NHS Fdn Trust, Royal Preston Hosp, Rosemere Canc Ctr, Preston PR2 9HT, Lancs, England

[10] Univ Manchester, Manchester, England

[11] Univ Cent Lancashire, Preston, England

[12] Royal Devon & Exeter NHS Fdn Trust, Royal Devon & Exeter Hosp, Exeter, England

[13] Univ Leeds, Leeds, England

[14] St James Univ Hosp, Leeds Teaching Hosp NHS Trust, Leeds, England

[15] Western Gen Hosp, NHS Lothian, Edinburgh, Scotland

[16] Royal Sussex Cty Hosp, Brighton & Sussex Univ Hosp NHS Trust, Brighton, England

[17] Sir Charles Gairdner Hosp, Nedlands, WA, Australia

[18] Mt Vernon Hosp, Natl Radiotherapy Trials Qual Assurance Grp RTTQA, Northwood, England

[19] Peter Maallum Canc Ctr, Melbourne, Vic, Australia

[20] TROG Canc Res, Waratah, NSW, Australia

来源：

EUROPEAN UROLOGY | 2025年 / 87卷 / 01期

关键词：

Adaptive radiotherapy; Image-guided radiotherapy; Radiotherapy; Randomised controlled trial; LONG-TERM OUTCOMES; GASTROINTESTINAL SYMPTOMS; RADIATION-THERAPY; QUESTIONNAIRE; VOLUME;

D O I：

10.1016/j.eururo.2024.09.006

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background and objective: Delivering radiotherapy to the bladder is challenging as it is a mobile, deformable structure. Dose-escalated adaptive image-guided radiotherapy could improve outcomes. RAIDER aimed to demonstrate the safety of such a schedule. Methods: RAIDER is an international phase 2 noncomparative randomised controlled trial (ISRCTN26779187). Patients with unifocal T2-T4a urothelial bladder cancer were randomised (1:1:2) to standard whole bladder radiotherapy (WBRT), standard-dose adaptive radiotherapy (SART), or dose-escalated adaptive radiotherapy (DART). Two fractionation (f) schedules recruited independently. WBRT and SART dose was 55 Gy/20f or 64 Gy/32f, and DART dose was 60 Gy/20f or 70 Gy/32f. For SART and DART, a radiotherapy plan (small, medium, or large) was chosen daily. The primary endpoint was the proportion of patients with radiotherapy-related late Common Terminology Criteria for Adverse Events grade >= 3 toxicity; the trial was designed to rule Key findings and limitations: A total of 345 patients were randomised between October 2015 and April 2020: 41/46 WBRT, 41/46 SART, and 81/90 DART patients in the 20f/32f

引用

页码：60 / 70

页数：11

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