Enantioselective Desymmetrization of Phosphinic Acids via Cu-Catalyzed O-Arylation

被引：0

作者：

Yan, Ming ^{[1
]}

Zou, Jia-wei ^{[2
]}

Fang, Dong-mei ^{[1
]}

Zhang, Shi-qi ^{[1
]}

Cui, Xin ^{[1
]}

Tang, Zhuo ^{[1
]}

Li, Guang-xun ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Biol, Biol Resources Applying Ctr, Chengdu 610041, Sichuan, Peoples R China

[2] Leshan Normal Univ, Dept New Energy Mat & Chem, Leshan 614004, Sichuan, Peoples R China

来源：

ACS CATALYSIS | 2025年 / 15卷 / 06期

关键词：

Enantioselective desymmetrization; Copper catalysis; Chiral phosphorus compounds; Diaryliodonium salt; Phosphinic acid; EFFICIENT ASYMMETRIC-SYNTHESIS; P-STEREOGENIC PHOSPHINAMIDES; CHIRAL PHOSPHINES; P(O)-OH COMPOUNDS; OXIDES; ACCESS; LIGANDS; AMINOPHOSPHINES; CYCLIZATION; INHIBITORS;

D O I：

10.1021/acscatal.5c00439

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Enantioselective desymmetrization of phosphinic acid with two completely different carbon substituents on the P atom is an efficient way to obtain chiral P(V) compounds with high structural diversity. Herein, we reported a Cu-catalyzed asymmetric arylation of phosphinic acid, which turns the P-center to be a versatile electrophile for obtaining a series of chiral P(V) compounds, including phosphinates, phosphinamides, and tertiary phosphine oxides, in good yields and high enantioselectivities.

引用

页码：4719 / 4725

页数：7

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