The Association Between Serum Polychlorinated Biphenyls and Incident Cardiovascular Disease Among Type 2 Diabetes

被引:0
作者
An, Jun [1 ,2 ]
Zhang, Shiyang [1 ,2 ]
Cheng, Xu [1 ,2 ]
Jia, Chengyong [1 ,2 ]
Zhang, Xin [1 ,2 ]
Yan, Yan [1 ,2 ]
Zhao, Zhuoya [1 ,2 ]
Liu, Yuenan [1 ,2 ]
Guan, Youbing [1 ,2 ]
Li, Peiwen [1 ,2 ]
Zhang, Jin [1 ,2 ]
He, Meian [1 ,2 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China
关键词
Polychlorinated biphenyls; PCBs; Cardiovascular disease; CVD; Type; 2; diabetes; T2D; cohort analysis; cardiovascular epidemiology; PERSISTENT ORGANIC POLLUTANTS; DIETARY EXPOSURE; MYOCARDIAL-INFARCTION; RISK; POPULATION; STROKE; METABOLITES; COHORT; PCBS;
D O I
10.1210/clinem/dgaf014
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Polychlorinated biphenyls (PCBs) are associated with cardiovascular disease (CVD) in the general population. However, it is unclear whether PCB exposure increases the additional risk of CVD among type 2 diabetes (T2D) cases. This study aims to investigate the associations between serum concentrations of PCBs and incident CVD among T2D cases.Methods The study population was derived from the Dongfeng-Tongji cohort in 2008 and followed up until December 31, 2018, with a total of 2806 participants with T2D included; 1180 of them developed CVD during the follow-up. Cox proportional hazard regression models and quantile g-computation method were conducted for the associations of serum PCB levels with incident CVD risk.Results Compared with the first quartile, the risk of incident CVD was increased by 25%, 30%, and 28% in the fourth quartile of serum concentrations of PCB28, PCB52, and PCB101, respectively. Similar results were obtained for lower-chlorinated PCBs (PCB28 + PCB52 + PCB101) with a hazard ratio (95% confidence interval) of 1.257 (1.063, 1.486) and 1.346 (1.139, 1.589) in the third and fourth quartiles, respectively (P trend = .001). Quantile g-computation indicated that mixed exposure to PCBs increased the risk of CVD, and the top 3 weights of PCB congeners were PCB101, PCB52, and PCB28.Conclusion Serum PCB independently increased the risk of incident CVD among T2D cases, in which lower-chlorinated PCBs played a dominant role.
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页数:10
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