Clinical Value of Mir-320a Combined with HMGB1 in Diagnosis and Prognosis of Severe Acute Pancreatitis Complicated with Sepsis

被引：0

作者：

Chen, Mingdi ^{[1
]}

Huang, Rongxian ^{[2
]}

Zeng, Wenchi ^{[1
]}

Wu, Xiaodeng ^{[1
]}

Xie, Huawen ^{[1
]}

Li, Shiting ^{[1
]}

Li, Zhuoji ^{[1
]}

机构：

[1] Guangdong Med Univ, Affiliated Hosp 2, Dept Crit Care Med, 12 Minyou Rd, Zhanjiang 524003, Guangdong, Peoples R China

[2] Xinxing Community Hlth Serv Ctr, Dept Clin Lab, Zhanjiang 524000, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF HUMAN GENETICS | 2024年 / 24卷 / 03期

关键词：

HMGB1; Interleukin-6 (IL-6); microRNA-320a; Severe Acute Pancreatitis; Sepsis; INJURY; RATS;

D O I：

10.31901/24566322.2024/24.03.892

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Severe acute pancreatitis (SAP) often leads to sepsis in severe cases. This study investigated the clinical potential of combining miR-320a with HMGB1 in diagnosing and predicting the prognosis of SAP complicated with sepsis (SAP-CS). Serum levels of miR-320a were found to be decreased, while HMGB1 levels were increased in patients with SAP-CS. The combination of miR-320a and HMGB1 showed promise in diagnosing SAP-CS (AUC = 0.9634, sensitivity = 90.70%, specificity = 93.02%). Specifically, miR-320a levels were downregulated and HMGB1 levels were elevated in patients with a poor prognosis. Furthermore, the low miR-320a group had a worse prognosis, and miR-320a, HMGB1, and IL-6 were independent factors influencing poor prognoses. Therefore, miR-320a combined with HMGB1 has the potential to be a clinical indicator for diagnosing and predicting the prognosis of SAP-CS.

引用

页码：292 / 298

页数：7