Enzyme-based colorimetric signal amplification strategy in lateral flow immunoassay

被引:0
作者
Gong, Haijiang [1 ]
Zeng, Qingtan [2 ]
Gai, Shili [1 ,3 ]
Du, Yaqian [1 ]
Zhang, Jing [1 ]
Wang, Qingyu [1 ]
Ding, He [1 ]
Wu, Lichun [4 ]
Ansari, Anees Ahmad [5 ]
Yang, Piaoping [1 ,3 ]
机构
[1] Harbin Engn Univ, Coll Mat Sci & Chem Engn, Key Lab Superlight Mat & Surface Technol, Minist Educ, Harbin 150001, Peoples R China
[2] Navy Mil Med Univ, Changhai Hosp, Shanghai 200086, Peoples R China
[3] Harbin Engn Univ, Yantai Res Inst, Yantai 264000, Peoples R China
[4] Univ Elect Sci & Technol China, Sichuan Canc Ctr, Sichuan Canc Hosp & Inst, Sch Med,Dept Clin Lab, Chengdu 610041, Peoples R China
[5] King Saud Univ, King Abdullah Inst Nanotechnol, Riyadh 11451, Saudi Arabia
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Lateral flow immunoassay; Signal amplification; Enzyme-based enhancement; Catalysis; Colorimetric signal; ULTRASENSITIVE DETECTION; FLUORESCENCE; ASSAYS; PROBE; ACID; DNA;
D O I
10.1016/j.cclet.2024.110059
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Lateral flow immunoassay (LFIA), a rapid detection technique noted for simplicity and economy, has showcased indispensable applicability in diverse domains such as disease screening, food safety, and environmental monitoring. Nevertheless, challenges still exist in detecting ultra-low concentration analytes due to the inherent sensitivity limitations of LFIA. Recently, significant advances have been achieved by integrating enzyme activity probes and transforming LFIA into a highly sensitive tool for rapidly detecting trace analyte concentrations. Specifically, modifying natural enzymes or engineered nanozymes allows them to function as immune probes, directly catalyzing the production of signal molecules or indirectly initiating enzyme activity. Therefore, the signal intensity and detection sensitivity of LFIA are markedly elevated. The present review undertakes a comprehensive examination of pertinent research literature, offering a systematic analysis of recently proposed enzyme-based signal amplification strategies. By way of comparative assessment, the merits and demerits of current approaches are delineated, along with the identification of research avenues that still need to be explored. It is anticipated that this critical overview will garner considerable attention within the biomedical and materials science communities, providing valuable direction and insight toward the advancement of high-performance LFIA technologies. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
引用
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页数:10
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