Oral self-management of palbociclib using mobile technology: Findings from a nurse-led randomized controlled trial

Objective: Test the feasibility and effectiveness of a text message reminder intervention for the self-management of oral anticancer medication in patients with metastatic breast cancer. Methods: Forty-three females initiating treatment with palbociclib participated in a two-armed prospective randomized clinical trial. Participants were randomized into the control (n = 21) and intervention groups (n = 22) from January 2020 to January 2023. Survey responses were collected at three-time points; (1) at consent, (2) end of treatment cycles, and (3) at a follow-up clinic visit. Surveys included a demographic questionnaire, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, post-study assessment, and the R-15 Participant Satisfaction Questionnaire. Nurse providers completed the Adaptation of Stamps Nurse Workload questionnaire. Results: The COVID-19 pandemic and regulatory decisions supporting other CDK4/6 medications negatively influence recruitment; thus, a small sample for each arm only detected large differences between the two arms regarding effectiveness. Feasibility analysis was not conducted due to insufficient data, but the participants frequently used their smartphones for text messaging. Although the survey data were limited, participants provided anecdotal information supporting the use of text messaging as a positive method to remind them to take their medication, have their labs drawn, and attend MD visits. Participants would have liked text messages at the exact time they took their medications as a simple reminder. Conclusions: Given the importance of cancer treatments and the difficulties patients experience during these treatments, text messages using smartphones can actively improve patients'engagement and their ability to manage their treatment regimens. Trial registration: ClinicalTrials.gov; ID: NCT04216576.