Longitudinal waning of mRNA vaccine-induced neutralizing antibodies against SARS-CoV-2 detected by an LFIA rapid test

被引：7

作者：

Wang, Qiao ^{[1
]}

Feng, Lili ^{[2
]}

Zhang, Haohai ^{[2
]}

Gao, Juehua ^{[3
]}

Mao, Changchuin ^{[4
]}

Landesman-Bollag, Esther ^{[5
]}

Mostoslavsky, Gustavo ^{[6
]}

Lunderberg, Justin M. ^{[2
]}

Zheng, Weina ^{[1
]}

Hao, Shushun ^{[1
]}

Gao, Wenda ^{[4
]}

机构：

[1] Shijiazhuang Hipro Biotechnol Co Ltd, Shijiazhuang 050035, Hebei, Peoples R China

[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA

[4] Antagen Diagnost Inc, Canton, MA 02021 USA

[5] Boston Univ, Med Ctr, Dept Med, Boston, MA 02118 USA

[6] Boston Univ, Ctr Regenerat Med, Sch Med, Boston, MA 02118 USA

来源：

ANTIBODY THERAPEUTICS | 2022年 / 5卷 / 01期

关键词：

SARS-CoV-2; mRNA vaccine; neutralizing antibody; LFIA; rapid test;

D O I：

10.1093/abt/tbac004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although mRNA vaccines against SARS-CoV-2 were highly efficacious against severe illness and hospitalization, they seem to be less effective in preventing infection months after vaccination, especially with the Delta variant. Breakthrough infections might be due to higher infectivity of the variants, relaxed protective measures by the general public in "COVID-19 fatigue", and/or waning immunity post-vaccination. Determining the neutralizing antibody levels in a longitudinal manner may address this issue, but technical complexity of classic assays precludes easy detection and quick answers. We developed a lateral flow immunoassay NeutraXpress (TM) (commercial name of the test kit by Antagen Diagnostics, Inc.) and tested fingertip blood samples of subjects receiving either Moderna or Pfizer vaccines at various time points. With this device, we confirmed the reported clinical findings that mRNA vaccine-induced neutralizing antibodies quickly wane after 3-6 months. Thus, using rapid tests to monitor neutralizing antibody status could help identify individuals at risk, prevent breakthrough infections, and guide social behavior to curtail the spread of COVID-19.

引用

页码：55 / 62

页数：8

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