The history of cytokines and growth factors development

被引：0
作者：
Kungwankiattichai, Smith [1 ,2 ]
Maziarz, Richard T. [1 ]
机构：
[1] Oregon Hlth & Sci Univ, Knight Canc Inst, Ctr Hematol Malignancies, Portland, OR 97239 USA
[2] Mahidol Univ, Fac Med, Div Hematol, Dept Med,Siriraj Hosp, Bangkok, Thailand
来源：
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2025年 / 38卷 / 01期
关键词：
Cytokines; Growth factors; Immunotherapy; Hematopoiesis; Cytokine signaling; JAK-STAT pathway; Recombinant cytokines; Anti-cytokine therapy; Molecular cloning; COLONY-STIMULATING FACTOR; TUMOR-NECROSIS-FACTOR; STEM-CELL FACTOR; CYTOSINE-ARABINOSIDE; BONE-MARROW; BIOLOGICAL-ACTIVITIES; FUSION PROTEIN; GM-CSF; CHEMOTHERAPY; FILGRASTIM;
D O I：
10.1016/j.beha.2025.101612
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The discovery and development of cytokines and growth factors represent transformative events in modern medicine, spanning from early observations of immune mediators to current therapeutic applications. This review chronicles the historical progression from the initial identification of permeability factors in 1926 to contemporary engineered cytokine therapeutics. Key milestones include the discovery of interferon (1957), the characterization of colony-stimulating factors, and the development of recombinant proteins in the 1980s. The field has evolved from basic understanding of immune communication to sophisticated therapeutic interventions, including targeted inhibitors and engineered cell therapies. While significant advances have been made in treating various diseases through cytokine modulation, challenges remain in managing pleiotropic effects and optimizing delivery systems. Recent innovations in bioengineering and cell therapy suggest promising directions for future therapeutic applications.
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页数：8
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  • [1] Cohen M.C., Cohen S., Cytokine function: a study in biologic diversity, Am J Clin Pathol, 105, pp. 589-598, (1996)
  • [2] Rahman T., Das A., Abir M.H., Nafiz I.H., Mahmud A.R., Sarker M.R., Et al., Cytokines and their role as immunotherapeutics and vaccine Adjuvants: the emerging concepts, Cytokine, 169, (2023)
  • [3] Zinsser H., Tamiya T., An experimental analysis of bacterial allergy, J Exp Med, 44, pp. 753-776, (1926)
  • [4] Menkin V., Chemical basis of fever, Science, 100, pp. 337-338, (1944)
  • [5] Isaacs A., Lindenmann J., Virus interference. I. The interferon, Proceedings of the Royal Society of London Series B-Biological Sciences, 147, pp. 258-267, (1957)
  • [6] Haller O., A tribute to Jean Lindenmann, co-discoverer of interferon (1924–2015), Cytokine, 76, pp. 113-115, (2015)
  • [7] Bloom B.R., Bennett B., Mechanism of a reaction in vitro associated with delayed-type hypersensitivity, Science, 153, pp. 80-82, (1966)
  • [8] Dumonde D., Wolstencroft R., Panayi G., Matthew M., Morley J., Howson W., “Lymphokines”: non-antibody mediators of cellular immunity generated by lymphocyte activation, Nature, 224, pp. 38-42, (1969)
  • [9] Cohen S., Bigazzi P.E., Yoshida T., Similarities of T cell function in cell-mediated immunity and antibody production, Cell Immunol, 12, pp. 150-159, (1974)
  • [10] Sarraf C., Tumor-necrosis-factor and cell-death in tumors, Int J Oncol, 5, pp. 1333-1339, (1994)
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