Biological activity of vanadium pincer complexes

被引：0

作者：

Delgado-Rangel, Luis Humberto ^{[1
]}

Reyes-Marquez, Viviana ^{[2
]}

Moreno-Narvaez, Maria Esther ^{[1
]}

Aragon-Muriel, Alberto ^{[3
]}

Parra-Unda, Jesus R. ^{[4
]}

Cruz-Navarro, J. Antonio ^{[1
]}

Martinez-Torres, Mayra A. ^{[1
]}

Valdes, Hugo ^{[5
]}

Morales-Morales, David ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ,Circuito Exterior S-N, Ciudad De Mexico 04510, Mexico

[2] Univ Sonora, Dept Ciencias Quim Biol, Luis Encinas & Rosales S-N, Hermosillo 83000, Mexico

[3] Univ Magdalena, Grp Invest Bioquim GIB, Santa Marta 470004, Colombia

[4] Univ Autonoma Sinaloa, Fac Ciencias Quim Biol, Unidad Invest Salud Publ Dra Kaethe Willms, Culiacan 80010, Mexico

[5] Univ Alcala, Fac Farm, Dept Quim Organ & Quim Inorgan, Inst Invest Quim Andres M del Rio IQAR, Alcala De Henares 28805, Madrid, Spain

来源：

NEW JOURNAL OF CHEMISTRY | 2025年 / 49卷 / 09期

关键词：

HETEROLEPTIC OXIDOVANADIUM(IV) COMPLEXES; HETEROCYCLIC CARBENE COMPLEXES; TRYPANOSOMA-CRUZI; CRYSTAL-STRUCTURE; SALICYLALDEHYDE SEMICARBAZONES; COPPER(II) COMPLEXES; POLYPYRIDYL LIGANDS; CLICK CHEMISTRY; CARBON-DIOXIDE; DNA CLEAVAGE;

D O I：

10.1039/d4nj04551c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review focuses on the biological activity of vanadium pincer complexes, exploring their applications as activators or inhibitors of enzymatic function, antioxidants, and agents with potential therapeutic effects. Specifically, their capacities as antidiabetic, antibacterial, antiviral, antiparasitic, and anticancer agents are examined in detail. The use of pincer ligands for biological applications has grown enormously in the last ten years, as these ligands can confer to the complexes they form properties such as enhanced stability, improved bioavailability, and greater specificity for pharmacological targets, potentially leading to pharmacological synergy. Additionally, the use of vanadium in the development of pharmacologically active compounds has gained attention due to its role in certain biological processes and its ability to interact with proteins by mimicking phosphorus atoms, making vanadium-containing molecules of significant interest for further study.

引用

页码：3442 / 3455

页数：14

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