Nickel/Photo-Cocatalyzed Cross-Coupling of Enol Silyl Ethers with α-Trifluoromethyl Bromides to Access β-CF3-Substituted Ketones

被引：1

作者：

Jiang, Yan ^{[1
]}

Liao, Youzhi ^{[1
]}

Zhao, Yi ^{[1
]}

Pan, Fei ^{[1
]}

机构：

[1] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610068, Peoples R China

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 06期

基金：

中国国家自然科学基金;

关键词：

COPPER-CATALYZED TRIFLUOROMETHYLATION; RING-OPENING TRIFLUOROMETHYLATION; RADICAL TRIFLUOROMETHYLATION; SUBSTITUTED KETONES; FACILE SYNTHESIS; GENERATION; EFFICIENT; CF3;

D O I：

10.1021/acs.orglett.4c04220

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we introduce a nickel-photocatalyzed cross-coupling reaction between enol silyl ethers and CF3-substituted alkyl bromides. This method provides a streamlined approach for synthesizing a wide array of structurally diverse beta-CF3-substituted ketones, achieving favorable yields under mild conditions. The practicality of this methodology is further underscored by its successful application in the late-stage functionalization of various pharmaceuticals and natural products.

引用

页码：1344 / 1349

页数：6