Targeting Ferroptosis in Rare Neurological Disorders Including Pediatric Conditions: Innovations and Therapeutic Challenges

被引：1

作者：

Alatawi, Ahmed D. ^{[1
]}

Venkatesan, Krishnaraju ^{[2
]}

Asseri, Khalid ^{[2
]}

Paulsamy, Premalatha ^{[3
]}

Alqifari, Saleh F. ^{[4
]}

Ahmed, Rehab ^{[5
]}

Nagoor Thangam, Mathar Mohideen ^{[6
]}

Sirag, Nizar ^{[5
]}

Qureshi, Absar A. ^{[2
]}

Elsayes, Hala Ahmed ^{[7
,8
]}

Faried Bahgat, Zeinab ^{[9
,10
]}

Bahnsawy, Nesren S. M. ^{[11
,12
]}

Prabahar, Kousalya ^{[4
]}

Dawood, Basma Mahmoud Abd Elhamid ^{[13
,14
]}

机构：

[1] Jouf Univ, Coll Pharm, Dept Clin Pharm, Sakaka 72388, Saudi Arabia

[2] King Khalid Univ, Coll Pharm, Dept Pharmacol, Abha 62521, Saudi Arabia

[3] King Khalid Univ, Coll Nursing, Mahalah Branch Girls, Abha 62521, Saudi Arabia

[4] Univ Tabuk, Fac Pharm, Dept Pharm Pract, Tabuk 71491, Saudi Arabia

[5] Univ Tabuk, Fac Pharm, Dept Nat Prod & Alternat Med, Tabuk 71491, Saudi Arabia

[6] Univ Tabuk, Fac Nursing, Dept Med Surg Nursing, Tabuk 71491, Saudi Arabia

[7] King Abdulaziz Univ, Dept Psychiat & Mental Hlth Nursing, Jeddah 21589, Saudi Arabia

[8] Tanta Univ, Fac Nursing, Dept Pediat Nursing, Tanta 31527, Egypt

[9] Tanta Univ, Fac Nursing, Dept Med Surg Nursing, Tanta 31527, Egypt

[10] King Saud Bin Abdul Aziz Univ Hlth Sci KSAU HS, Coll Nursing, King Abdullah Int Med Res Ctr, Dept Med Surg Nursing, Al Hasa 31982, Saudi Arabia

[11] King Saud Bin Abdul Aziz Univ Hlth Sci KSAU HS, Coll Nursing, King Abdullah Int Med Res Ctr, Dept Pediat Nursing, Riyadh 11481, Saudi Arabia

[12] Cairo Univ, Fac Nursing, Dept Pediat Nursing, Giza, Egypt

[13] Tanta Univ, Fac Nursing, Dept Pediat Nursing, Tanta 31527, Egypt

[14] King Saud Bin Abdul Aziz Univ Hlth Sci KSAU HS, Coll Med, King Abdullah Int Med Res Ctr KAIMRC, Dept Med Educ, Jeddah, Saudi Arabia

来源：

BIOMEDICINES | 2025年 / 13卷 / 02期

关键词：

ferroptosis; rare neurological disorders; lipid peroxidation; iron metabolism; GLUTATHIONE-PEROXIDASE; 4; NEURONAL CEROID-LIPOFUSCINOSIS; LIPID-PEROXIDATION; CELL-DEATH; REDOX BIOLOGY; IRON; DISEASE; FORM; GPX4; PROGRESSION;

D O I：

10.3390/biomedicines13020265

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ferroptosis, characterized by iron dependency and lipid peroxidation, has emerged as a key mechanism underlying neurodegeneration in rare neurological disorders. These conditions, often marked by significant therapeutic gaps and high unmet medical needs, present unique challenges for intervention development. This review examines the involvement of ferroptosis in rare neurological disease pathogenesis, focusing on its role in oxidative damage and neuronal dysfunction. We explore recent pharmacological advancements, including iron chelators, lipid peroxidation blockers, and antioxidant-based strategies, designed to target ferroptosis. While these approaches show promise, challenges such as disease heterogeneity, limited diagnostic tools, and small patient cohorts hinder progress. Furthermore, we discuss the translational and regulatory barriers to implementing ferroptosis-based therapies in clinical practice. By addressing these obstacles and fostering innovative solutions, this review underscores the potential of ferroptosis-targeting strategies to revolutionize treatment paradigms for rare neurological disorders.

引用

页数：22

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