A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium

被引：20

作者：

Zhang, Le ^{[1
,2
]}

Guo, Jun ^{[3
]}

Liu, Yuehong ^{[4
]}

Sun, Shimin ^{[5
]}

Liu, Baohua ^{[6
]}

Yang, Qi ^{[4
]}

Tao, Jun ^{[7
]}

Tian, Xiao-Li ^{[8
,9
,10
]}

Pu, Jun ^{[11
]}

Hong, Huashan ^{[12
]}

Wang, Miao ^{[13
,14
]}

Chen, Hou-Zao ^{[15
,16
]}

Ren, Jie ^{[17
,18
]}

Wang, Xiaoming ^{[19
]}

Liang, Zhen ^{[20
]}

Wang, Yuan ^{[21
]}

Huang, Kai ^{[22
,23
,24
,25
]}

Zhang, Weiqi ^{[17
,18
]}

Qu, Jing ^{[26
]}

Ju, Zhenyu ^{[27
]}

Liu, Guang-Hui ^{[28
,29
,30
]}

Pei, Gang ^{[31
]}

Li, Jian ^{[3
]}

Zhang, Cuntai ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Geriatr, Tongji Med Coll, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Minist Educ,Key Lab Vasc Aging, Wuhan 430030, Peoples R China

[3] Chinese Acad Med Sci, Natl Ctr Gerontol,Natl Hlth Commiss, Beijing Inst Geriatr,Beijing Hosp, Inst Geriatr Med,Key Lab Geriatr, Beijing 100730, Peoples R China

[4] Capital Med Univ, Beijing Chaoyang Hosp, Dept Radiol, Beijing 100020, Peoples R China

[5] Jena Univ Hosp, Inst Mol Cell Biol, Ctr Mol Biomed, D-07743 Jena, Germany

[6] Shenzhen Univ, Sch Basic Med Sci, Med Sch, Shenzhen 518055, Peoples R China

[7] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Hypertens & Vasc Dis, Guangzhou 510080, Peoples R China

[8] Nanchang Univ, Human Aging Res Inst HARI, Aging & Vasc Dis, Nanchang 330031, Jiangxi, Peoples R China

[9] Nanchang Univ, Sch Life Sci, Nanchang 330031, Jiangxi, Peoples R China

[10] Jiangxi Key Lab Human Aging, Nanchang 330031, Jiangxi, Peoples R China

[11] Shanghai Jiao Tong Univ, Shanghai Canc Inst, Renji Hosp,Sch Med, Div Cardiol,State Key Lab Syst Med Canc, Shanghai 200127, Peoples R China

[12] Fujian Med Univ, Fujian Key Lab Vasc Aging, Dept Geriatr, Union Hosp, Fuzhou 350001, Peoples R China

[13] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China

[14] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Clin Pharmacol Ctr, Natl Ctr Cardiovasc Dis, Beijing 100037, Peoples R China

[15] Chinese Acad Med Sci Peking Union Med Coll, Inst Basic Med Sci, State Key Lab Common Mech Res Major Dis, Dept Biochem & Mol Biol, Beijing 100005, Peoples R China

[16] Chinese Acad Med Sci, Med Epigenet Res Ctr, Beijing 100005, Peoples R China

[17] Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China

[18] China Natl Ctr Bioinformat, Beijing 100101, Peoples R China

[19] Air Force Med Univ, Xijing Hosp, t Geriatr, Xian 710032, Peoples R China

[20] Shenzhen Peoples Hosp, Shenzhen 518020, Peoples R China

[21] Capital Med Univ, Beijing Anzhen Hosp, Beijing 100029, Peoples R China

[22] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Clin Ctr Human Gene Res, Wuhan 430022, Peoples R China

[23] Huazhong Univ Sci & Technol, Hubei Key Lab Metab Abnormal & Vasc Aging, Wuhan 430022, Peoples R China

[24] Huazhong Univ Sci & Technol, Hubei Clin Res Ctr Metab & Cardiovasc Dis, Wuhan 430022, Peoples R China

[25] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiol, Wuhan 430022, Peoples R China

[26] Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China

[27] Jinan Univ, Inst Aging & Regenerat Med, Key Lab Regenerat Med, Minist Educ, Guangzhou 510632, Peoples R China

[28] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[29] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China

[30] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China

[31] Tongji Univ, Sch Life Sci & Technol, Collaborat Innovat Ctr Brain Sci, Shanghai 200092, Peoples R China

来源：

LIFE MEDICINE | 2023年 / 2卷 / 04期

关键词：

PULSE-WAVE VELOCITY; ANKLE-BRACHIAL INDEX; ENDOTHELIAL PROGENITOR CELLS; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR-DISEASE RISK; ALL-CAUSE MORTALITY; ARTERIAL STIFFNESS; AORTIC STIFFNESS; CORONARY ATHEROSCLEROSIS; INDEPENDENT PREDICTOR;

D O I：

10.1093/lifemedi/lnad033

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aging of the vasculature, which is integral to the functioning of literally all human organs, serves as a fundamental physiological basis for age-related alterations as well as a shared etiological mechanism for various chronic diseases prevalent in the elderly population. China, home to the world's largest aging population, faces an escalating challenge in addressing the prevention and management of these age-related conditions. To meet this challenge, the Aging Biomarker Consortium of China has developed an expert consensus on biomarkers of vascular aging (VA) by synthesizing literature and insights from scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with VA and presents a systemic framework to classify them into three dimensions: functional, structural, and humoral. Within each dimension, the expert panel recommends the most clinically relevant VA biomarkers. For the functional domain, biomarkers reflecting vascular stiffness and endothelial function are highlighted. The structural dimension encompasses metrics for vascular structure, microvascular structure, and distribution. Additionally, proinflammatory factors are emphasized as biomarkers with the humoral dimension. The aim of this expert consensus is to establish a foundation for assessing the extent of VA and conducting research related to VA, with the ultimate goal of improving the vascular health of the elderly in China and globally.

引用

页数：23

共 219 条

[91] Medial Arterial Calcification JACC State-of-the-Art Review [J].

Lanzer, Peter ;

Hannan, M. Fadil ;

Lanzer, D. Jan ;

Janzen, Jan ;

Raggi, Paolo ;

Furniss, Dominic ;

Schuchardt, Mirjam ;

Thakker, Rajesh ;

Fok, Pak-Wing ;

Saez-Rodriguez, Julio ;

Millan, Angel ;

Sato, Yu ;

Ferraresi, Roberto ;

Virmani, Renu ;

St. Hilaire, Cynthia .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 78 (11) :1145-1165

[92] Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients [J].

Laurent, S ;

Boutouyrie, P ;

Asmar, R ;

Gautier, I ;

Laloux, B ;

Guize, L ;

Ducimetiere, P ;

Benetos, A .

HYPERTENSION, 2001, 37 (05) :1236-1241

[93] Expert consensus document on arterial stiffness: methodological issues and clinical applications [J].

Laurent, Stephane ;

Cockcroft, John ;

Van Bortel, Luc ;

Boutouyrie, Pierre ;

Giannattasio, Cristina ;

Hayoz, Daniel ;

Pannier, Bruno ;

Vlachopoulos, Charalambos ;

Wilkinson, Ian ;

Struijker-Boudier, Harry .

EUROPEAN HEART JOURNAL, 2006, 27 (21) :2588-2605

[94] An epigenetic biomarker of aging for lifespan and healthspan [J].

Levine, Morgan E. ;

Lu, Ake T. ;

Quach, Austin ;

Chen, Brian H. ;

Assimes, Themistocles L. ;

Bandinelli, Stefania ;

Hou, Lifang ;

Baccarelli, Andrea A. ;

Stewart, James D. ;

Li, Yun ;

Whitsel, Eric A. ;

Wilson, James G. ;

Reiner, Alex P. ;

Aviv, Abraham ;

Lohman, Kurt ;

Liu, Yongmei ;

Ferrucci, Luigi ;

Horvath, Steve .

AGING-US, 2018, 10 (04) :573-591

[95] Reduced white matter venous density on MRI is associated with neurodegeneration and cognitive impairment in the elderly [J].

Li, Chenyang ;

Rusinek, Henry ;

Chen, Jingyun ;

Bokacheva, Louisa ;

Vedvyas, Alok ;

Masurkar, Arjun V. ;

Haacke, E. Mark ;

Wisniewski, Thomas ;

Ge, Yulin .

FRONTIERS IN AGING NEUROSCIENCE, 2022, 14

[96] Histological validation of simultaneous non-contrast angiography and intraplaque hemorrhage imaging (SNAP) for characterizing carotid intraplaque hemorrhage [J].

Li, Dongye ;

Qiao, Huiyu ;

Han, Yongjun ;

Han, Hualu ;

Yang, Dandan ;

Cao, Jingli ;

Xu, Huimin ;

Wang, Tao ;

Wang, Yajie ;

Shen, Jun ;

Zhao, Xihai .

EUROPEAN RADIOLOGY, 2021, 31 (05) :3106-3115

[97] 1H NMR-Based Metabolomics Reveals the Intrinsic Interaction of Age, Plasma Signature Metabolites, and Nutrient Intake in the Longevity Population in Guangxi, China [J].

Li, He ;

Ren, Minhong ;

Li, Quanyang .

NUTRIENTS, 2022, 14 (12)

[98] Determining a multimodal aging clock in a cohort of Chinese women [J].

Li, Jiaming ;

Xiong, Muzhao ;

Fu, Xiang-Hong ;

Fan, Yanling ;

Dong, Chen ;

Sun, Xiaoyan ;

Zheng, Fang ;

Wang, Si-Wei ;

Liu, Lixiao ;

Xu, Ming ;

Wang, Cui ;

Ping, Jiale ;

Che, Shanshan ;

Wang, Qiaoran ;

Yang, Kuan ;

Zuo, Yuesheng ;

Lu, Xiaoyong ;

Zheng, Zikai ;

Lan, Tian ;

Wang, Si ;

Ma, Shuai ;

Sun, Shuhui ;

Zhang, Bin ;

Chen, Chen-Shu ;

Cheng, Ke-Yun ;

Ye, Jinlin ;

Qu, Jing ;

Xue, Yongbia ;

Yang, Yun-Gui ;

Zhang, Feng ;

Zhang, Weiqi ;

Liu, Guang-Hui .

MED, 2023, 4 (11) :825-+

[99] Inflammation and aging: signaling pathways and intervention therapies [J].

Li, Xia ;

Li, Chentao ;

Zhang, Wanying ;

Wang, Yanan ;

Qian, Pengxu ;

Huang, He .

SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 8 (01)

[100] Potential urinary aging markers of 20-month-old rats [J].

Li, Xundou ;

Gao, Youhe .

PEERJ, 2016, 4

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