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Esketamine Treatment Trajectory of Patients with Treatment-Resistant Depression in the Mid and Long-Term Run: Data from REAL-ESK Study Group
被引：0
作者：
Rosso, Gianluca
[1
,2
]
d'Andrea, Giacomo
[3
,4
]
Barlati, Stefano
[5
,6
]
Di Nicola, Marco
[7
,8
]
Andriola, Ileana
[9
]
Marcatili, Matteo
[10
]
Martiadis, Vassilis
[11
]
Olivola, Miriam
[12
,13
]
Di Mauro, Stefania
[14
]
Di Salvo, Gabriele
[1
,2
]
De Fazio, Pasquale
[15
]
Clerici, Massimo
[8
,16
]
Dell'Osso, Bernardo Maria
[17
]
Vita, Antonio
[5
,6
]
Di Lorenzo, Giorgio
[17
,18
]
Pettorruso, Mauro
[3
,4
,19
]
Martinotti, Giovanni
[3
,4
,20
,21
]
Maina, Giuseppe
[1
,2
]
机构：
[1] Univ Torino, Dept Neurosci Rita Levi Montalcini, Turin, Italy
[2] San Luigi Gonzaga Univ Hosp, Psychiat Unit, Turin, Italy
[3] Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy
[4] ASL 2 Abruzzo Lanciano Vasto, Dept Mental Hlth, Chieti, Italy
[5] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy
[6] ASST Spedali Civili Brescia, Dept Mental Hlth & Addict Serv, Brescia, Italy
[7] Univ Cattolica Sacro Cuore, Dept Neurosci, Sect Psychiat, Rome, Italy
[8] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Psychiat, Rome, Italy
[9] Univ Bari Aldo Moro, Dept Translat Biomed & Neurosci, Aldo Moro, Italy
[10] Fdn IRCCS San Gerardo Tintori, Dept Mental Hlth & Addict, Monza, Italy
[11] ASL Napoli 1 Ctr, Dept Mental Hlth, Naples, Italy
[12] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy
[13] Azienda Sociosanit Territoriale ASST, Dept Mental Hlth & Addict, Pavia, Italy
[14] SPDC Frosinone ASL Frosinone, Frosinone, Italy
[15] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Psychiat Unit, Catanzaro, Italy
[16] Univ Milano Bicocca, Sch Med & Surg, Monza, Italy
[17] Univ Milan, Aldo Ravelli Ctr Neurotechnol & Brain Therapeut, Dept Biomed & Clin Sci Luigi Sacco, Milan, Italy
[18] Univ Roma Tor Vergata, Chair Psychiat, Dept Syst Med, Rome, Italy
[19] IRCCS Fdn Santa Lucia, Rome, Italy
[20] G Annunzio Univ Chieti Pescara, Inst Adv Biomed Technol ITAB, Chieti, Pescara, Italy
[21] Univ Hertfordshire, Sch Life & Med Sci, Drug Misuse & Novel Psychoact Subst Res Unit, Psychopharmacol, Hatfield AL10 9AB, Herts, England
关键词：
Major depressive disorder;
treatment-resistant depression;
antidepressants;
esketamine;
maintenance treatment;
treatment outcome;
EUROPEAN COHORT;
WORLD EVIDENCE;
NASAL SPRAY;
SAFETY;
D O I：
10.2174/011570159X337670241029062524
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Introduction/Objective Data on long-term treatment with Esketamine Nasal Spray (ESK-NS) in real-world patients with treatment resistant depression (TRD) is scarce. The primary aim of the study is to evaluate the effectiveness and tolerability of ESK-NS treatment at 6 and 12-month follow-ups.Methods This is part of an observational, retrospective, multicentric Italian study (REAL-ESK study). Subjects for the present study underwent psychiatric assessments after 6 and 12 months from the start of ESK-NS treatment. Repeated measures analysis of variance (ANOVA) was used to assess changes in continuous variables, such as scores on psychometric scales from baseline to follow-up time points.Results Of 63 patients who maintained ESK-NS treatment for at least 6 months, 48 were responders or remitters (76.2%). Among 15 non-responders at 6 months, 4 significantly improved at 12-month follow-up. At least one side effect was reported by 71.8% of subjects with a 6-month follow-up assessment. An overall reduction of side effects was noticed as treatment progressed (42% of patients who continued the treatment reported side effects at 12 months). The most common side effects were sedation (31.7%) and dissociation (28.6%) during ESK-NS sessions. Only 2 patients discontinued ESK-NS for tolerability reasons.Conclusion The results support the effectiveness and safety of esketamine in the mid and long-term treatment of TRD patients. The late clinical response of a subgroup of patients represents a novel finding. Data needs to be confirmed in larger samples and longer observation periods.
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页码：612 / 619
页数：8
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