Interactive strategies to teach nurse residents about evidence-based practice (EBP) can instill the confidence to question practice and ensure best care for patients. A nurse residency program with the Mission Possible theme transformed nurses into EBP agents that must solve the EBP process, step-by-step. Clues interspersed with didactic lessons guide the teams through the EBP mission. This creative option for teaching EBP may assist other educators in finding interactive learning opportunities for this content.