m6A methyltransferase METTL3 promotes non-small-cell lung carcinoma progression by inhibiting the RIG-I-MAVS innate immune pathway

被引：3

作者：

Huang, Tinghui ^{[1
]}

Ao, Xudong ^{[2
]}

Liu, Jie ^{[1
]}

Sun, Chuancheng ^{[1
]}

Dong, Yunfei ^{[1
]}

Yin, Xuechen ^{[1
]}

Zhang, Yan ^{[1
]}

Wang, Xinping ^{[1
]}

Li, Wenying ^{[1
]}

Cao, Jiujiu ^{[1
]}

Pan, Feiyan ^{[1
]}

Hu, Zhigang ^{[1
]}

Guo, Zhigang ^{[1
]}

He, Lingfeng ^{[1
]}

机构：

[1] Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Mol & Med Biotechnol, 1 WenYuan Rd, Nanjing 210023, Peoples R China

[2] Peking Univ, Inner Mongolia Med Univ, Canc Hosp, Affiliated Canc Hosp, Inner Mongolia Campus,42 Zhaowuda Rd, Hohhot 010010, Inner Mongolia, Peoples R China

来源：

TRANSLATIONAL ONCOLOGY | 2025年 / 51卷

关键词：

METTL3; RIG-I-MAVS; NSCLC; Tumor therapy; CANCER;

D O I：

10.1016/j.tranon.2024.102230

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Our experimental study showed that METTL3 was highly expressed in NSCLC cells and promoted the growth of tumor cells. METTL3 takes N6-methyladenosine (m6A) as the main means of mRNA modification to control the expression and function of RIG-I-MAVS signalling pathway. RIG-I-MAVS constitute the first line frontier in the innate immune defense of human cells. Activation of RIG-I-MAVS signaling can inhibit tumor cell growth and activate the immune microenvironment. Our experimental data reveal that lung cancer cells utilize METTL3mediated methylation modifications to inhibit the activation of RIG-I-MAVS signaling pathway and immune responses. Our work provides new ideas for biotherapy and immunotherapy.

引用

页数：12

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