Histone deacetylase in inflammatory bowel disease: novel insights

被引：0

作者：

Li, Chunxiao ^{[2
]}

Gu, Shaobo ^{[3
]}

Zhang, Yihong ^{[1
]}

Zhang, Zhenruo ^{[4
]}

Wang, Junzhuo ^{[2
]}

Gao, Ting ^{[2
]}

Zhong, Kangpeng ^{[2
]}

Shan, Keshu ^{[2
]}

Ye, Guoliang ^{[2
]}

Ke, Yini ^{[5
]}

Chen, Yi ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Gastroenterol, 79 Qingchun Rd, Hangzhou 310003, Peoples R China

[2] Ningbo Univ, Dept Gastroenterol, Affiliated Hosp 1, Ningbo, Zhejiang, Peoples R China

[3] Ningbo 2 Hosp, Dept Orthoped, Ningbo, Zhejiang, Peoples R China

[4] Ningbo Univ, Arrhythmia Ctr, Affiliated Hosp 1, Ningbo, Zhejiang, Peoples R China

[5] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Rheumatol, Hangzhou, Zhejiang, Peoples R China

来源：

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY | 2025年 / 18卷

基金：

中国国家自然科学基金;

关键词：

HDAC inhibitors (HDACis); histone deacetylases (HDACs); inflammatory bowel disease (IBD); T cell function; DSS-INDUCED COLITIS; COLONIC INFLAMMATION; IN-VITRO; INHIBITION; CELLS; POLARIZATION; MACROPHAGES; EXPRESSION; CANCER; ACID;

D O I：

10.1177/17562848251318833

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is characterized by chronic nonspecific intestinal inflammation. Despite considerable efforts, IBD remains a heavy burden on society and human health, with increasing morbidity. Posttranslational modification, especially histone acetylation, is a key process in controlling DNA transcriptional activity. Histone deacetylases (HDACs) play a vital role in the mechanism of IBD pathogenesis through histone and nonhistone protein deacetylation. Herein, we present a summary of different categories of HDACs as well as HDAC inhibitors (HDACis) and analyze the role of HDAC inhibition in alleviating IBD along with its mechanism, as well as clinical potential of HDACis in IBD treatment.

引用

页数：18

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