A new cadinane-type sesquiterpenoid glucoside from Centaurea alexandrina

被引：0

作者：

Saleh, Ibrahim A. ^{[1
]}

Elsayed, Wael M. ^{[1
]}

Hussien, Taha A. ^{[2
]}

Elshamy, Abdelsamed I. ^{[3
]}

Mohamed, Tarik A. ^{[1
]}

Hegazy, Mohamed-Elamir F. ^{[1
]}

机构：

[1] Natl Res Ctr, Chem Med Plants Dept, 33 El Bohouth St, Giza 12622, Egypt

[2] Sphinx Univ, Fac Pharm, Dept Pharmacognosy, Assiut, Egypt

[3] Natl Res Ctr, Dept Nat Cpds Chem, Giza, Egypt

来源：

NATURAL PRODUCT RESEARCH | 2024年

关键词：

Asteraceae; <italic>Centaurea alexandrina</italic>; sesquiterpenes; cadinane-type sesquiterpene glucoside; cytotoxicity; ASTERACEAE DISTRIBUTION; SECONDARY METABOLITES; TRIBE CARDUEAE; LACTONES; CONSTITUENTS; FLAVONOIDS;

D O I：

10.1080/14786419.2024.2440930

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new cadinane-type sesquiterpene glucoside, 10 alpha-hydroxy, 1 alpha(H), 6 beta(H), 7 beta(H), 8 beta(H)-cadinane-4-en-8-O-beta-D-glucoside (1) as well as, 2 known analogues [sinaicin (2)- linichlorinA (3)], were isolated from the CH2Cl2:MeOH organic extract of Centaurea alexandrina. Chemical structures of all isolated compounds were established depending upon the spectroscopic data including, 1D and 2D NMR and HRMS. Colo-205 (colorectal cancer), HepG2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) and cancer cell lines were used to test the cytotoxic potential of the isolated compounds (1-3).

引用

页数：7

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