A new cadinane-type sesquiterpenoid glucoside from Centaurea alexandrina

被引：0
|
作者：
Saleh, Ibrahim A. [1 ]
Elsayed, Wael M. [1 ]
Hussien, Taha A. [2 ]
Elshamy, Abdelsamed I. [3 ]
Mohamed, Tarik A. [1 ]
Hegazy, Mohamed-Elamir F. [1 ]
机构：
[1] Natl Res Ctr, Chem Med Plants Dept, 33 El Bohouth St, Giza 12622, Egypt
[2] Sphinx Univ, Fac Pharm, Dept Pharmacognosy, Assiut, Egypt
[3] Natl Res Ctr, Dept Nat Cpds Chem, Giza, Egypt
来源：
NATURAL PRODUCT RESEARCH | 2024年
关键词：
Asteraceae; <italic>Centaurea alexandrina</italic>; sesquiterpenes; cadinane-type sesquiterpene glucoside; cytotoxicity; ASTERACEAE DISTRIBUTION; SECONDARY METABOLITES; TRIBE CARDUEAE; LACTONES; CONSTITUENTS; FLAVONOIDS;
D O I：
10.1080/14786419.2024.2440930
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new cadinane-type sesquiterpene glucoside, 10 alpha-hydroxy, 1 alpha(H), 6 beta(H), 7 beta(H), 8 beta(H)-cadinane-4-en-8-O-beta-D-glucoside (1) as well as, 2 known analogues [sinaicin (2)- linichlorinA (3)], were isolated from the CH2Cl2:MeOH organic extract of Centaurea alexandrina. Chemical structures of all isolated compounds were established depending upon the spectroscopic data including, 1D and 2D NMR and HRMS. Colo-205 (colorectal cancer), HepG2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) and cancer cell lines were used to test the cytotoxic potential of the isolated compounds (1-3).
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