Associations Between Urinary Pesticide Metabolites and Serum Inflammatory Biomarkers in Adolescents Living in an Agricultural Region

被引:0
作者
Hussari, Mohammed N. [1 ]
Chronister, Briana N. C. [2 ,3 ]
Yang, Kun [2 ]
Tu, Xin [2 ]
Martinez, Danilo [4 ]
Parajuli, Rajendra P. [2 ]
Suarez-Torres, Jose [4 ]
Barr, Dana Boyd [5 ]
Hong, Suzi [2 ,6 ]
Suarez-Lopez, Jose R. [2 ]
机构
[1] Univ Calif San Diego UCSD, Sch Med, 9500 Gillman Dr, San Diego, CA 92093 USA
[2] Univ Calif San Diego UCSD, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, 9500 Gillman Dr MC 0725, San Diego, CA 92093 USA
[3] San Diego State Univ, Sch Publ Hlth, San Diego, CA USA
[4] Fdn Cimas Ecuador CIMAS, Olivos E14-226y, Quito 170124, Pichincha, Ecuador
[5] Emory Univ, Rollins Sch Publ Hlth, 1518 Clifton Rd NE, Atlanta, GA 30322 USA
[6] Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92093 USA
基金
美国国家卫生研究院;
关键词
Inflammation; Pesticides; Agriculture; Ecuador; Cytokines; Adolescents; C-REACTIVE PROTEIN; RISK-FACTORS; ACETYLCHOLINESTERASE ACTIVITY; PARKINSONS-DISEASE; BODY-FAT; EXPOSURE; CHILDREN; CYPERMETHRIN; EXPRESSION; WORKERS;
D O I
10.1007/s12403-025-00698-0
中图分类号
TV21 [水资源调查与水利规划];
学科分类号
081501 ;
摘要
In-vitro and in-vivo studies have shown evidence for the immuno-modulatory properties of different pesticides. However, few epidemiological studies on inflammation and pesticide exposure exist, with none in children and adolescents. Associations between pesticide metabolites in urine and inflammatory biomarkers in serum were evaluated among children and adolescents (n = 512) of rural Ecuador as part of the ESPINA study. Seventeen urinary biomarkers of insecticide, herbicide and N,N-diethyl-meta-toluamide (DEET) insect repellent exposure were measured. Among them, acetamiprid-N-desmethyl [AND], 3,5,6-Trichloro-2-pyridinol [TCPy], para-nitrophenol [PNP], malathion dicarboxylic acid [MDA], 3-phenoxybenzoic acid [3-PBA], 2,4-Dichlorophenoxyacetic acid [2,4-D], glyphosate and 3-(diethylcarbamoyl) benzoic acid [DCBA] were included in analyses as they were detected in > 30% of participants. Serum analysis included c-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), serum amyloid A (SAA), and soluble CD14 (sCD14). Associations were evaluated by generalized estimating equations (GEE) and partial least squares (PLS) regression, adjusting for demographic, anthropometric and socioeconomic variables. Positive quadratic associations were found between 2,4-D and CRP (beta(2) = 0.13, [0.00, 0.27]), IL-6 (beta(2) = 0.10, [0.04, 0.15]), SAA (beta(2) = 0.13, [0.01, 0.30]), sICAM-1 (beta(2) = 53.25, [27.26, 79.24]) and sVCAM-1 (beta(2) = 61.11, [30.52, 91.70]). The pesticide metabolites PLS composite variable was positively associated with IL-6 (beta = 0.09, [0.01. 0.17]), SAA (beta = 0.43, [0.13, 0.17]), sICAM-1 (beta = 63.52, [9.92, 117.13]), sVCAM-1 (beta = 69.03, [8.29, 129.76]), and TNF-alpha (beta = 0.08, [0.00, 0.16]), and negatively associated with CRP (beta = - 0.28, [- 0.49, - 0.08]). Our findings demonstrate a novel pesticide/herbicide-inflammation link in adolescents, which may be an underlying mechanism of the health impacts of pesticides/herbicides.
引用
收藏
页数:18
相关论文
共 88 条
[1]   Cyclosporine A and MnTMPyP Alleviate α-Synuclein Expression and Aggregation in Cypermethrin-Induced Parkinsonism [J].
Agrawal, Sonal ;
Dixit, Anubhuti ;
Singh, Ashish ;
Tripathi, Pratibha ;
Singh, Dhirendra ;
Patel, Devendra Kumar ;
Singh, Mahendra Pratap .
MOLECULAR NEUROBIOLOGY, 2015, 52 (03) :1619-1628
[2]   Cypermethrin-Induced Nigrostriatal Dopaminergic Neurodegeneration Alters the Mitochondrial Function:A Proteomics Study [J].
Agrawal, Sonal ;
Singh, Ashish ;
Tripathi, Pratibha ;
Mishra, Manisha ;
Singh, Pradhyumna Kumar ;
Singh, Mahendra Pratap .
MOLECULAR NEUROBIOLOGY, 2015, 51 (02) :448-465
[3]   Muscular fitness, fatness and inflammatory biomarkers in adolescents [J].
Artero, E. G. ;
Espana-Romero, V. ;
Jimenez-Pavon, D. ;
Martinez-Gomez, D. ;
Warnberg, J. ;
Gomez-Martinez, S. ;
Gonzalez-Gross, M. ;
Vanhelst, J. ;
Kafatos, A. ;
Molnar, D. ;
De Henauw, S. ;
Moreno, L. A. ;
Marcos, A. ;
Castillo, M. J. .
PEDIATRIC OBESITY, 2014, 9 (05) :391-400
[4]   Glyphosate-based herbicides induces autophagy in IPEC-J2 cells and the intervention of N-acetylcysteine [J].
Bai, Guangdong ;
Zhou, Ruiying ;
Jiang, Xu ;
Zou, Yingbin ;
Shi, Baoming .
ENVIRONMENTAL TOXICOLOGY, 2022, 37 (08) :1878-1890
[5]   Quantification of DEET and neonicotinoid pesticide biomarkers in human urine by online solid-phase extraction high-performance liquid chromatography-tandem mass spectrometry [J].
Baker, Samuel E. ;
Serafim, Amanda Bishop ;
Morales-Agudelo, Pilar ;
Vidal, Meghan ;
Calafat, Antonia M. ;
Ospina, Maria .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2019, 411 (03) :669-678
[6]   Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases-A mechanistic approach [J].
Baltazar, Maria Teresa ;
Dinis-Oliveira, Ricardo Jorge ;
Bastos, Mariade Lourdes ;
Tsatsakis, Aristidis M. ;
Duarte, Jose Alberto ;
Carvalho, Felix .
TOXICOLOGY LETTERS, 2014, 230 (02) :85-103
[7]   Association Between Occupational Exposure to Pesticides and Cardiovascular Disease Incidence: The Kuakini Honolulu Heart Program [J].
Berg, Zara K. ;
Rodriguez, Beatriz ;
Davis, James ;
Katz, Alan R. ;
Cooney, Robert V. ;
Masaki, Kamal .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2019, 8 (19)
[8]   Effects of 2,4-D and its metabolite 2,4-dichlorophenol on antioxidant enzymes and level of glutathione in human erythrocytes [J].
Bukowska, M .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2003, 135 (04) :435-441
[9]   Overweight Latino children and adolescents have marked endothelial dysfunction and subclinical vascular inflammation in association with excess body fat and insulin resistance [J].
Caballero, A. Enrique ;
Bousquet-Santos, Kelb ;
Robles-Osorio, Ludivina ;
Montagnani, Valeria ;
Soodini, Geetha ;
Porramatikul, Sriurai ;
Hamdy, Osama ;
Nobrega, Antonio C. L. ;
Horton, Edward S. .
DIABETES CARE, 2008, 31 (03) :576-582
[10]   Toxic effects of pesticides on cellular and humoral immunity: an overview [J].
Cestonaro, Larissa Vivan ;
Macedo, Sandra Manoela Dias ;
Piton, Yasmin Vendrusculo ;
Garcia, Solange Cristina ;
Arbo, Marcelo Dutra .
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2022, 44 (06) :816-831