Epstein-Barr virus infection in patients with MOGAD

被引：1

作者：

Maniscalco, Giorgia T. ^{[1
,2
]}

Dinoto, Alessandro ^{[3
]}

Foglia, Maria C. ^{[4
]}

Di Battista, Maria E. ^{[1
,2
]}

Moreggia, Ornella

Di Giulio Cesare, Daniele

Williams, Michela ^{[5
,6
]}

Rossi, Francesca W. ^{[5
,6
]}

Carta, Sara ^{[3
]}

Chiodega, Vanessa ^{[3
]}

Ferrari, Sergio ^{[3
]}

Viola, Assunta ^{[7
]}

de Paulis, Amato ^{[5
,6
]}

Andreone, Vincenzo ^{[1
]}

Mariotto, Sara ^{[3
]}

机构：

[1] A Cardarelli Hosp, Multiple Sclerosis Reg Ctr, Neurol Clin & Stroke Unit, Via A Cardarelli 9, I-80131 Naples, Italy

[2] A Cardarelli Hosp, Multiple Sclerosis Ctr, Naples, Italy

[3] Univ Verona, Neurol Unit, Biomed & Movement Sci, Verona, Italy

[4] A Cardarelli Hosp, Clin Pathol & Microbiol Lab, Naples, Italy

[5] Univ Naples Federico II, Dept Translat Med Sci, Sect Clin Immunol, Naples, Italy

[6] Univ Naples Federico II, Ctr Basic & Clin Immunol Res CISI, WAO Ctr Excellence, Naples, Italy

[7] A Cardarelli Hosp, Mol Biol Lab Hematol & Transplantat CSE, Naples, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2025年 / 31卷 / 01期

关键词：

Epstein-Barr virus; EBV; EBNA-1; VCA; MOGAD; MOG; myelin oligodendrocyte glycoprotein; serology;

D O I：

10.1177/13524585241298065

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Epstein-Barr virus (EBV) infection increases the risk of having multiple sclerosis (MS). Data on adults with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are lacking. Objective: To compare EBV serological status in MOGAD versus MS. Methods: We measured antibodies to Epstein-Barr nuclear antigen (EBNA-1) and viral capsid antigen (VCA) antigens in 129 patients (MS = 74, MOGAD = 55) by chemiluminescence immunoassays. Results: VCA-IgG were detected in 97.3% of MS and 96.4% of MOGAD cases, while EBNA-1-IgG in 97.3% of MS and 80% of MOGAD (p = 0.001). EBNA-1 (p < 0.001) and VCA (p = 0.03) antibodies levels were higher in MS patients. Conclusion: EBV antibodies are higher in MS versus MOGAD, suggesting a possible different role of EBV in the pathogenesis of the two conditions.

引用

页码：117 / 120

页数：4

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