An overview of the most used synthetic pathways of 1,2,4-triazolo[1,5-a] pyrimidines

被引：1
作者：
Zedan, Mohamed N. [1 ]
Shoman, Mai E. [2 ]
Abdel-Aziz, Mohamed [2 ]
Abdel-Rahman, Hamdy M. [3 ,4 ]
机构：
[1] Portsaid Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Portsaid 42526, Egypt
[2] Minia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt
[3] Assiut Univ, Fac Pharm, Dept Med Chem, Assiut 71526, Egypt
[4] Badr Univ Assiut BUA, Fac Pharm, Dept Pharmaceut Chem, Assiut 2014101, Egypt
来源：
RESULTS IN CHEMISTRY | 2024年 / 12卷
关键词：
3(5)-Amino-1; 2; 4-triazole (AT); Pyrimidine; Synthesis; BEARING BRIDGEHEAD NITROGEN; DIHYDROOROTATE DEHYDROGENASE INHIBITORS; MICROWAVE-ASSISTED SYNTHESIS; BIOLOGICAL EVALUATION; PART; POTENT; TRIAZOLOPYRIMIDINE; DESIGN; AGENTS; CYCLOCONDENSATION;
D O I：
10.1016/j.rechem.2024.101903
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Among the all possible isomers of triazolopyrimidines, 1,2,4-triazolo[1,5-a]pyrimidines are the most important isomers owing to their vast activities in agriculture and medicinal chemistry. Herein, we present an overview of the most used synthetic pathways of this scaffold to assist researchers design new drug molecules with expected pharmacological activities
引用
收藏
页数：17
相关论文
共 156 条
  • [1] Aaij R, 2022, NAT PHYS, V18, P54, DOI 10.1038/s41567-021-01394-x
  • [2] Synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives: Antimicrobial activity, DNA Gyrase inhibition and molecular docking
    Abd El-Aleam, Rehab H.
    George, Riham F.
    Hassan, Ghaneya S.
    Abdel-Rahman, Hamdy M.
    [J]. BIOORGANIC CHEMISTRY, 2020, 94
  • [3] Abdel-Hafez AA, 2002, ARZNEIMITTELFORSCH, V52, P833
  • [4] Synthesis and antimicrobial evaluation of some new pyrimidines and condensed pyrimidines
    Abdelghani, Essam
    Said, Said Aly
    Assy, M. G.
    Hamid, Atef M. Abdel
    [J]. ARABIAN JOURNAL OF CHEMISTRY, 2017, 10 : S2926 - S2933
  • [5] Efficient Synthesis and Antimicrobial Evaluation of New Azolopyrimidines-Bearing Pyrazole Moiety
    Abdelhamid, Abdou O.
    Gomha, Sobhi M.
    El-Enany, Waleed A. M. A.
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56 (09) : 2487 - 2493
  • [6] Green One-Pot Solvent-Free Synthesis of Pyrazolo[1,5-a]pyrimidines, Azolo[3,4-d]pyridiazines, and Thieno[2,3-b]pyridines Containing Triazole Moiety
    Abdelhamid, Abdou O.
    El-Idreesy, Tamer T.
    Abdelriheem, Nadia A.
    Dawoud, Huda R. M.
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2016, 53 (03) : 710 - 718
  • [7] y Synthesis and Antimicrobial Evaluation of Novel Triazole, Tetrazole, and Spiropyrimidine-Thiadiazole Derivatives
    Abu-Hashem, Ameen A.
    El-Shazly, Mohamed
    [J]. POLYCYCLIC AROMATIC COMPOUNDS, 2021, 41 (03) : 478 - 497
  • [8] Ahmed GA, 1997, J INDIAN CHEM SOC, V74, P624
  • [9] Product and Mechanism of Gas-phase Pyrolysis of 2-arylidinehydrazinopyrimidines: Interesting Route to Condensed Heterocycles
    Al-Awadi, Sundus A.
    Ibrahim, Maher R.
    El-Dusouqui, Osman M. E.
    Al-Awadi, Nouria A.
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2015, 52 (06) : 1812 - 1816
  • [10] Studies with functionally substituted enamines: The reactivity of enaminals and enamino esters toward naphthoquinone, hydrazonoyl halides, aminoazoles and hippuric acid
    Al-Saleh, B
    Makhseed, S
    Hassaneen, HME
    Elnagdi, MH
    [J]. SYNTHESIS-STUTTGART, 2006, (01): : 59 - 62
12345678910