Risk factors and prognostic impact of low physical performance in elderly patients undergoing radical gastrectomy for gastric cancer

被引：0

作者：

Xia-Lin Yan ^{[1
]}

Chen-Hao He ^{[1
]}

Zong-Ze Li ^{[1
]}

Wen-Bo Zhai ^{[1
]}

Gao-Feng Wu ^{[1
]}

Wen-Tao Xi ^{[1
]}

Ding-Hao Chen ^{[2
]}

Zhang-Tao Chen ^{[2
]}

Xian Shen ^{[1
]}

Dong-Dong Huang ^{[1
]}

机构：

[1] Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou

[2] First School of Clinical Medicine, Wenzhou Medical University, Wenzhou

来源：

Supportive Care in Cancer | 2025年 / 33卷 / 5期

关键词：

Body composition; Elderly; Gastric cancer; Physical performance; Prognosis; Risk factor;

D O I：

10.1007/s00520-025-09437-2

中图分类号：

学科分类号：

摘要：

Purpose: The present study aims to investigate the prognostic impact of low physical performance in elderly patients undergoing radical gastrectomy for gastric cancer, and to explore the risk factors for low physical performance in these patients. Methods: Clinical data of 840 elderly patients (≥ 65 years) who underwent radical gastrectomy for gastric cancer were prospectively collected. Physical performance was assessed by 6-m usual gait speed test. Muscle strength was measured by grip strength test and chair rise test. Body composition was analyzed by preoperative computed tomography (CT). Results: Low physical performance was associated with higher incidence of ileus and severe complications after surgery. Low physical performance was independently associated with worse overall survival and disease-free survival after adjusting for age, gender, tumor–node–metastasis (TNM) stage, and histological differentiation of tumor. Physical performance had a significant correlation with skeletal muscle index (SMI), skeletal muscle density (SMD), chair rise time, and grip strength, but not with fat mass. Females, nutritional risk, chair rise time ≥ 15 s, low grip strength, low SMD, and higher TNM stage of tumor were independent risk factors for low physical performance in elderly patients with gastric cancer. Conclusion: Low physical performance was associated with worse postoperative outcomes in elderly patients undergoing radical gastrectomy for gastric cancer. Aging itself was not independently associated with low physical performance. Nutritional support, exercise strategies aiming to improve muscle strength and density, and anti-tumor treatments to reduce tumor burden could be beneficial to improve physical performance, which could further improve the prognosis in elderly patients with gastric cancer. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.

引用

共 31 条

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