Platelet-rich plasma combined with isometric quadriceps contraction regulates autophagy in chondrocytes via the PI3K/AKT/mTOR pathway to promote cartilage repair in knee osteoarthritis

被引:1
作者
Cheng, Liang [1 ,2 ,3 ]
Chang, Shuwan [1 ]
Tan, Yajun [4 ]
He, Benxiang [2 ]
机构
[1] Chengdu Sport Univ, Sch Sports Med & Hlth, Chengdu, Peoples R China
[2] Sichuan Acad Chinese Med Sci, Chengdu, Peoples R China
[3] Sichuan Sports Coll, Human Movement Sci, Chengdu, Peoples R China
[4] Chengdu Sport Univ, Affiliated Sport Hosp, Chengdu, Peoples R China
来源
REGENERATIVE THERAPY | 2025年 / 28卷
关键词
Platelet-rich plasm; Isometric contraction of quadricep; Autophagy; PI3K/AKT/MTOR; Knee Osteoarthritis; PATHOGENESIS; APOPTOSIS; EXERCISES;
D O I
10.1016/j.reth.2024.11.013
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
引用
收藏
页码:81 / 89
页数:9
相关论文
共 62 条
[1]  
Abdallah EA, 2023, Egypt J Phys Ther, V13, P28
[2]  
Abdelall HA, 2024, Tanta Scientific Nursing Journal, V32, P246
[3]   Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model [J].
Almonte-Becerril, M. ;
Navarro-Garcia, F. ;
Gonzalez-Robles, A. ;
Vega-Lopez, M. A. ;
Lavalle, C. ;
Kouri, J. B. .
APOPTOSIS, 2010, 15 (05) :631-638
[4]   Drugging the PI3K/AKT/mTOR Pathway in ER plus Breast Cancer [J].
Alves, Carla L. ;
Ditzel, Henrik J. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (05)
[5]   Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery [J].
Backe, Sarah J. ;
Sager, Rebecca A. ;
Heritz, Jennifer A. ;
Wengert, Laura A. ;
Meluni, Katherine A. ;
Aran-Guiu, Xavier ;
Panaretou, Barry ;
Woodford, Mark R. ;
Prodromou, Chrisostomos ;
Bourboulia, Dimitra ;
Mollapour, Mehdi .
CELL REPORTS, 2023, 42 (07)
[6]   Autophagy Is a Protective Mechanism in Normal Cartilage, and Its Aging-Related Loss Is Linked With Cell Death and Osteoarthritis [J].
Carames, Beatriz ;
Taniguchi, Noboru ;
Otsuki, Shuhei ;
Blanco, Francisco J. ;
Lotz, Martin .
ARTHRITIS AND RHEUMATISM, 2010, 62 (03) :791-801
[7]   Health-related quality of life among patients with knee osteoarthritis in Guangzhou, China: a multicenter cross-sectional study [J].
Chang, Jinghui ;
Yuan, Yuxin ;
Fu, Manru ;
Wang, Dong .
HEALTH AND QUALITY OF LIFE OUTCOMES, 2023, 21 (01)
[8]   Effects of platelet-rich plasma combined with isometric quadriceps contraction on cartilage in a rat model of knee osteoarthritis [J].
Cheng, Liang ;
Wang, Kun ;
Chang, Shuwan ;
Tan, Yajun ;
He, Benxiang .
REGENERATIVE THERAPY, 2024, 26 :469-477
[9]   Effects of Tai Chi and brisk walking on the bone mineral density of perimenopausal women: A randomized controlled trial [J].
Cheng, Liang ;
Chang, Shuwan ;
He, Benxiang ;
Yan, Yang .
FRONTIERS IN PUBLIC HEALTH, 2022, 10
[10]   Effects of different exercise methods at the same intensity on bone mineral density of lumbar vertebrae and proximal femur in elderly women [J].
Cheng, Liang ;
Chang, Shuwan ;
Gao, Zhanle ;
Wang, Chun ;
Wu, Chaoya ;
Yu, Liang .
MEDICINA DELLO SPORT, 2019, 72 (01) :37-+