UNITY: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings

被引：12

作者：

Abate, F. ^{[2
,54
]}

Adu-Amankwah, A. ^{[3
,54
]}

Ae-Ngibise, K. A. ^{[4
,54
]}

Agbokey, F. ^{[4
,54
]}

Agyemang, V. A. ^{[4
,54
]}

Agyemang, C. T. ^{[4
,54
]}

Akgun, C. ^{[5
,54
]}

Ametepe, J. ^{[54
]}

Arichi, T. ^{[7
,54
]}

Asante, K. P. ^{[4
,54
]}

Balaji, S. ^{[8
,54
]}

Baljer, L. ^{[54
]}

Basser, P. J. ^{[10
,54
]}

Beauchemin, J. ^{[54
]}

Bennallick, C. ^{[54
]}

Berhane, Y. ^{[54
]}

Boateng-Mensah, Y. ^{[54
]}

Bourke, N. J. ^{[54
]}

Bradford, L. ^{[12
,13
,54
]}

Bruchhage, M. M. K. ^{[14
,54
]}

Lorente, R. Cano ^{[11
,54
]}

Cawley, P. ^{[7
,54
]}

Cercignani, M. ^{[6
,54
]}

Sa, V. D. ^{[11
,54
]}

de Canha, A. ^{[15
,54
]}

de Navarro, N. ^{[16
,54
]}

Dean, D. C., III ^{[17
,54
]}

Delarosa, J. ^{[18
,54
]}

Donald, K. A. ^{[12
,13
,54
]}

Dvorak, A. ^{[54
]}

Edwards, A. D. ^{[54
]}

Field, D. ^{[54
]}

Frail, H. ^{[19
,54
]}

Freeman, B. ^{[20
,54
]}

George, T. ^{[21
,54
]}

Gholam, J. ^{[54
]}

Guerrero-Gonzalez, J. ^{[17
,54
]}

Hajnal, J. V. ^{[7
,54
]}

Haque, R. ^{[22
,54
]}

Hollander, W. ^{[23
,54
]}

Hoodbhoy, Z. ^{[24
,54
]}

Huentelman, M. ^{[25
,54
]}

Jafri, S. K. ^{[24
,54
]}

Jones, D. K. ^{[6
,54
]}

Joubert, F. ^{[26
,54
]}

Karaulanov, T. ^{[23
,54
]}

Kasaro, M. P. ^{[27
,54
]}

Knackstedt, S. ^{[54
]}

Kolind, S. ^{[54
]}

Koshy, B. ^{[28
,54
]}

机构：

[1] Bill & Melinda Gates Fdn, MNCH D&T, Seattle, WA USA

[2] Addis Continental Inst Publ Hlth, Addis Ababa, Ethiopia

[3] Korle Bu Teaching Hosp, Accra, Ghana

[4] Ghana Hlth Serv, Res & Dev Div, Kintampo Hlth Res Ctr, Kintampo, Bono, Ghana

[5] Flywheel io, Minneapolis, MN USA

[6] Cardiff Univ, Brain Res Imaging Ctr, Cardiff, Wales

[7] Kings Coll London, Ctr Developing Brain, London, England

[8] Univ British Columbia, Dept Neurol, Vancouver, BC, Canada

[9] Kings Coll London, Ctr Neuroimaging Sci, London, England

[10] Natl Inst Hlth, Washington, DC USA

[11] Adv Baby Imaging Lab, Providence, RI USA

[12] Univ Cape Town, Red Cross War Mem Childrens Hosp, Div Dev Paediat, Dept Paediat & Child Hlth, Cape Town, South Africa

[13] Univ Cape Town, Neurosci Inst, Cape Town, South Africa

[14] Stavanger Univ, Dept Psychol, Stavanger, Norway

[15] Univ Pretoria, Inst Cellular & Mol Med, Dept Med Immunol, Pretoria, South Africa

[16] Collect Minds Radiol, Lund, Sweden

[17] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA

[18] PATH, Seattle, WA USA

[19] Hyperfine io, Guilford, CT USA

[20] Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC USA

[21] Chris Hani Baragwanath Acad Hosp Univ, Dept Radiol, Fac Hlth Sci, Soweto, South Africa

[22] Int Ctr Diarrheal Dis Res Bangladesh Icddr b, Dhaka, Bangladesh

[23] CaliberMRI, Boulder, CO USA

[24] Aga Khan Univ, Dept Pediat & Child Hlth, Karachi, Pakistan

[25] TGen, Phoenix, AZ USA

[26] Univ Pretoria, Dept Biochem Microbiol & Genet, Ctr Bioinformat & Computat Biol, Pretoria, South Africa

[27] Univ N Carolina, Global Projects Zambia, Lusaka, Zambia

[28] Christian Med Coll & Hosp, Dev Paediat, Vellore, Tamil Nadu, India

[29] Int Soc Magnet Resonance Med, San Francisco, CA USA

[30] Harvard Med Sch, Brigham & Womens Hosp, Dept Pediat, Boston, MA USA

[31] Leiden Univ, Dept Radiol, Leiden, Netherlands

[32] Univ Southern Calif, Keck Sch Med, Dept Radiol, Los Angeles, CA USA

[33] Natl Childrens Hosp, Sheikh Zayed Inst Pediat Surg Innovat, Washington, DC USA

[34] Lund Univ, Med Radiat Phys, Lund, Sweden

[35] Univ Pretoria, Steve Biko Acad Hosp, Dept Radiol, Fac Hlth Sci, Pretoria, South Africa

[36] Kings Coll London, Inst Psychat Psychol & Neurosci, Dept Forens & Neurodev Sci, London, England

[37] Kalafong Hosp, Dept Paediat & Child Hlth, Pretoria, South Africa

[38] Univ Pretoria, Fac Hlth Sci, Pretoria, South Africa

[39] Univ Witwatersrand, Dept Paediat & Child Hlth, Chris Hani Baragwanath Acad Hosp, Johannesburg, South Africa

[40] Univ Witwatersrand, Fac Hlth Sci, Johannesburg, South Africa

[41] Makerere Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Kampala, Uganda

[42] Boston Childrens Hosp, Div Dev Med, Dept Med, Labs Cognit Neurosci, Boston, MA USA

[43] Univ Stellenbosch, Dept Obstet Gynaecol, Stellenbosch, South Africa

[44] Jaramogi Oginga Odinga Teaching & Referral Hosp, Kisumu, Kenya

[45] Univ Montreal, Fac Med, Dept Psychiat & Neurosci, Montreal, PQ, Canada

[46] Univ Montreal, Ctr Hosp Univ Sainte Justine, Montreal, PQ, Canada

[47] Training & Res Unit Excellence TRUE, Zomba, Malawi

[48] Univ Hosp Bonn, Expt Neonatol, Bonn, Germany

[49] Murdoch Childrens Res Inst, Melbourne, Vic, Australia

[50] Univ Stellenbosch, Dept Paediat & Child Hlth, Fac Med & Hlth Sci, Cape Town, South Africa

来源：

DEVELOPMENTAL COGNITIVE NEUROSCIENCE | 2024年 / 69卷

基金：

英国惠康基金; 比尔及梅琳达.盖茨基金会;

关键词：

Neurodevelopment; Child Health; Global Health; Healthy Development; Environmental Adversity; Low Field Magnetic Resonance Imaging; BAYLEY SCALES; CHILD UNDERNUTRITION; TODDLER DEVELOPMENT; GENDER-DIFFERENCES; DEVELOPMENT-III; BRAIN; INFANT; NUTRITION; IMAGE; ARCHITECTURE;

D O I：

10.1016/j.dcn.2024.101397

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health and evaluating interventional outcomes in public health studies, including those that may impact neurodevelopment. While physical growth generally reflects overall health and nutritional status, it lacks sensitivity and specificity to brain growth and developing cognitive skills and abilities. Psychometric tools, e.g., the Bayley Scales of Infant and Toddler Development, may afford more direct assessment of cognitive development but they require language translation, cultural adaptation, and population norming. Further, they are not always reliable predictors of future outcomes when assessed within the first 12-18 months of a child's life. Neuroimaging may provide more objective, sensitive, and predictive measures of neurodevelopment but tools such as magnetic resonance (MR) imaging are not readily available in many low and middle-income countries (LMICs). MRI systems that operate at lower magnetic fields (< 100mT) may offer increased accessibility, but their use for global health studies remains nascent. The UNITY project is envisaged as a global partnership to advance neuroimaging in global health studies. Here we describe the UNITY project, its goals, methods, operating procedures, and expected outcomes in characterizing neurodevelopment in sub-Saharan Africa and South Asia.

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