Cutaneous Squamous Cell Carcinoma Producing Granulocyte Colony-stimulating Factor and Parathyroid Hormone-related Protein: A Case Report and Literature Review

被引：0

作者：

Kumagai, Takuya ^{[1
,2
]}

Saito, Masaya ^{[1
]}

Sato, Takahiko

Inoue, Junichi ^{[4
]}

Ishikawa, Norihisa ^{[5
]}

Ono, Tsuyoshi ^{[1
]}

Kono, Michihiro ^{[3
]}

Takahashi, Naoto ^{[2
]}

机构：

[1] Municipal Omori Hosp, Dept Internal Med, Tokyo, Japan

[2] Akita Univ, Dept Hematol Nephrol & Rheumatol, Grad Sch Med, Akita, Japan

[3] Akita Univ, Dept Dermatol & Plast Surg, Grad Sch Med, Akita, Japan

[4] Municipal Omori Hosp, Dept Orthoped Surg, Tokyo, Japan

[5] Omagari Kousei Med Ctr, Dept Dermatol, Akita, Japan

来源：

INTERNAL MEDICINE | 2025年 / 64卷 / 12期

关键词：

hypercalcemia-leukocytosis syndrome; granulocyte-colony stimulating factor; paraneoplastic syndrome; parathyroid hormone-related protein; HYPERCALCEMIA-LEUKOCYTOSIS SYNDROME; HUMAN LUNG-CANCER; IL-6;

D O I：

10.2169/internalmedicine.3992-24

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report a case of cutaneous squamous cell carcinoma (SCC) characterized by paraneoplastic hypercalcemia-leukocytosis syndrome. The patient presented with systemic symptoms, including anorexia, a fever, and a tumoral lesion on the upper arm. Laboratory test results revealed hypercalcemia and leukocytosis. A tissue biopsy confirmed SCC, and further investigation revealed elevated parathyroid hormone-related protein (PTHrP) and granulocyte-colony stimulating factor (G-CSF) levels. Immunostaining demonstrated GCSF production by the tumor cells. Radiation therapy was administered, which improved leukocytosis and decreased G-CSF and PTHrP levels. Through a case report and literature review, we explored the clinical characteristics of tumors that produce G-CSF and PTHrP.

引用

页码：1933 / 1940

页数：8

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