Mechanisms underlying delirium in patients with critical illness

被引：4

作者：

Fan, Ying-Ying ^{[1
,2
]}

Luo, Ruo-Yu ^{[1
,2
]}

Wang, Meng-Tian ^{[2
]}

Yuan, Chao-Yun ^{[2
]}

Sun, Yuan-Yuan ^{[2
]}

Jing, Ji-Yong ^{[2
]}

机构：

[1] Zhejiang Chinese Med Univ, Sch Nursing, Hangzhou, Peoples R China

[2] Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Peoples Hosp, Hangzhou, Peoples R China

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2024年 / 16卷

关键词：

delirium; critical illness; cognition impairment; mechanism; review; SYSTEMIC INFLAMMATORY RESPONSE; ILL PATIENTS; OXIDATIVE STRESS; MELATONIN SECRETION; ACQUIRED WEAKNESS; SLEEP DISRUPTION; BRAIN; TRANSMISSION; ASSOCIATION; METABOLISM;

D O I：

10.3389/fnagi.2024.1446523

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Delirium is an acute, global cognitive disorder syndrome, also known as acute brain syndrome, characterized by disturbance of attention and awareness and fluctuation of symptoms. Its incidence is high among critically ill patients. Once patients develop delirium, it increases the risk of unplanned extubation, prolongs hospital stay, increases the risk of nosocomial infection, post-intensive care syndrome-cognitive impairment, and even death. Therefore, it is of great importance to understand how delirium occurs and to reduce the incidence of delirium in critically ill patients. This paper reviews the potential pathophysiological mechanisms of delirium in critically ill patients, with the aim of better understanding its pathophysiological processes, guiding the formulation of effective prevention and treatment strategies, providing a basis for clinical medication.

引用

页数：15

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