Chest compressions superimposed with sustained inflation during neonatal cardiopulmonary resuscitation: are we ready for a clinical trial?

被引:0
作者
Koo, Jenny [1 ]
Cheung, Po-Yin [2 ]
Pichler, Gerhard [3 ]
Solevag, Anne Lee [4 ]
Law, Brenda Hiu Yan [2 ]
Katheria, Anup C. [5 ]
Schmolzer, Georg M. [6 ]
机构
[1] Sharp Mary Birch Hosp Women & Newborns, San Diego, CA USA
[2] Univ Alberta, Dept Pediat, Edmonton, AB, Canada
[3] Med Univ Graz, Pediat, Graz, Austria
[4] Akershus Univ Hosp, Dept Paediat & Adolescent Med, Lorenskog, Norway
[5] Sharp Mary Birch, Neonatol, San Diego, CA USA
[6] Royal Alexandra Hosp, Neonatol, Edmonton, AB, Canada
关键词
Neonatology; Resuscitation; HIGH AIRWAY PRESSURE; 100-PERCENT OXYGEN; DELIVERY ROOM; TIDAL VOLUME; VENTILATION RATIO; NEWBORN-INFANTS; PRETERM INFANTS; PORCINE MODEL; SWINE MODEL; RECOVERY;
D O I
暂无
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Neonates requiring cardiopulmonary resuscitation (CPR) are at risk of mortality and neurodevelopmental injury. Poor outcomes following the need for chest compressions (CCs) in the delivery room prompt the critical need for improvements in resuscitation strategies. This article explores a technique of CPR which involves CCs with sustained inflation (CC+SI). Unique features of CC+SI include (1) improved tidal volume delivery, (2) passive ventilation during compressions, (3) uninterrupted compressions and (4) improved stability of cerebral blood flow during resuscitation. CC+SI has been shown in animal studies to have improved time to return of spontaneous circulation and reduced mortality without significant increase in markers of inflammation and injury in the lung and brain, compared with standard CPR. The mechanics of CCs, rate of compressions, ventilation strategies and compression-to-ventilation ratios are detailed here. A large randomised controlled trial comparing CC+SI versus the current 3:1 compression-to-ventilation ratio is needed, given the growing evidence of its potential benefits.
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页码:2 / 7
页数:6
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