Recovery of Antibody Immunity After a Resurgence of Respiratory Syncytial Virus Infections

被引：0
|
作者：
Reicherz, Frederic [1 ,2 ,3 ]
Paramo, Marina Vineta [1 ,4 ]
Bone, Jeffrey N. [1 ]
Lavoie, Alexanne [1 ,2 ]
Li, Sirui [1 ,2 ]
Golding, Liam [1 ]
Jassem, Agatha [5 ,6 ]
Watts, Allison [1 ,2 ]
Abu-Raya, Bahaa [1 ,2 ]
Lavoie, Pascal M. [1 ,2 ]
机构：
[1] British Columbia Childrens Hosp, Res Inst, Vancouver, BC, Canada
[2] Univ British Columbia, Fac Med, Dept Pediat, Vancouver, BC, Canada
[3] Univ Witten Herdecke, Childrens Hosp Datteln, Dept Pediat, Witten, Germany
[4] Univ British Columbia, Women & Child Hlth Sci, Vancouver, BC, Canada
[5] British Columbia Ctr Dis Control, Publ Hlth Lab, Vancouver, BC, Canada
[6] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada
来源：
JOURNAL OF INFECTIOUS DISEASES | 2025年
基金：
加拿大健康研究院;
关键词：
respiratory syncytial virus; immunity; neutralization; Fc function; antibody;
D O I：
10.1093/infdis/jiaf101
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Longitudinal measurements of respiratory syncytial virus (RSV) immunity over 4 winter seasons reveal that viral neutralization titers, RSV prefusion F protein (pre-F)-specific immunoglobulin M and immunoglobulin G (IgG) levels, and RSV antibody-dependent cellular phagocytosis function gradually returned to prepandemic levels in female healthcare and school workers of childbearing age after 2 winter seasons, following the resurgence of RSV cases in the Vancouver metropolitan region (British Columbia, Canada). In contrast, pre-F IgG avidity profiles remained unchanged. These findings support the notion that repeated viral infections are necessary to maintain high RSV antibody levels in the population. Longitudinal antibody measurements in women of childbearing age show that respiratory syncytial virus (RSV) immunity returned to prepandemic levels following a resurgence of cases, supporting the conclusion that repeated viral infections are necessary to maintain high RSV antibody levels.
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页数：6
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