Recovery of Antibody Immunity After a Resurgence of Respiratory Syncytial Virus Infections

被引：0
|
作者：
Reicherz, Frederic [1 ,2 ,3 ]
Paramo, Marina Vineta [1 ,4 ]
Bone, Jeffrey N. [1 ]
Lavoie, Alexanne [1 ,2 ]
Li, Sirui [1 ,2 ]
Golding, Liam [1 ]
Jassem, Agatha [5 ,6 ]
Watts, Allison [1 ,2 ]
Abu-Raya, Bahaa [1 ,2 ]
Lavoie, Pascal M. [1 ,2 ]
机构：
[1] British Columbia Childrens Hosp, Res Inst, Vancouver, BC, Canada
[2] Univ British Columbia, Fac Med, Dept Pediat, Vancouver, BC, Canada
[3] Univ Witten Herdecke, Childrens Hosp Datteln, Dept Pediat, Witten, Germany
[4] Univ British Columbia, Women & Child Hlth Sci, Vancouver, BC, Canada
[5] British Columbia Ctr Dis Control, Publ Hlth Lab, Vancouver, BC, Canada
[6] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada
来源：
JOURNAL OF INFECTIOUS DISEASES | 2025年
基金：
加拿大健康研究院;
关键词：
respiratory syncytial virus; immunity; neutralization; Fc function; antibody;
D O I：
10.1093/infdis/jiaf101
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Longitudinal measurements of respiratory syncytial virus (RSV) immunity over 4 winter seasons reveal that viral neutralization titers, RSV prefusion F protein (pre-F)-specific immunoglobulin M and immunoglobulin G (IgG) levels, and RSV antibody-dependent cellular phagocytosis function gradually returned to prepandemic levels in female healthcare and school workers of childbearing age after 2 winter seasons, following the resurgence of RSV cases in the Vancouver metropolitan region (British Columbia, Canada). In contrast, pre-F IgG avidity profiles remained unchanged. These findings support the notion that repeated viral infections are necessary to maintain high RSV antibody levels in the population. Longitudinal antibody measurements in women of childbearing age show that respiratory syncytial virus (RSV) immunity returned to prepandemic levels following a resurgence of cases, supporting the conclusion that repeated viral infections are necessary to maintain high RSV antibody levels.
引用
收藏
页数：6
相关论文
共 50 条
  • [21] Placental Transfer of Respiratory Syncytial Virus Antibody Among HIV-Exposed, Uninfected Infants
    Patel, Sweta M.
    Jallow, Sabelle
    Boiditswe, Sefelani
    Madhi, Shabir A.
    Feemster, Kristen A.
    Steenhoff, Andrew P.
    Arscott-Mills, Tonya
    Muthoga, Charles
    Ajibola, Gbolahan
    Shapiro, Roger
    Shah, Samir S.
    Cunningham, Coleen K.
    Kelly, Matthew S.
    JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2020, 9 (03) : 349 - 356
  • [22] Respiratory Syncytial Virus Transplacental Antibody Transfer and Kinetics in Mother-Infant Pairs in Bangladesh
    Chu, Helen Y.
    Steinhoff, Mark C.
    Magaret, Amalia
    Zaman, Khalequ
    Roy, Eliza
    Langdon, Gretchen
    Formica, Mary Anne
    Walsh, Edward E.
    Englund, Janet A.
    JOURNAL OF INFECTIOUS DISEASES, 2014, 210 (10) : 1582 - 1589
  • [23] Pulmonary immunity and immunopathology: lessons from respiratory syncytial virus
    Olson, Matthew R.
    Varga, Steven M.
    EXPERT REVIEW OF VACCINES, 2008, 7 (08) : 1239 - 1255
  • [24] HUMORAL IMMUNITY TO RESPIRATORY SYNCYTIAL VIRUS-INFECTION IN THE ELDERLY
    FALSEY, AR
    WALSH, EE
    JOURNAL OF MEDICAL VIROLOGY, 1992, 36 (01) : 39 - 43
  • [25] Comparison of strain-specific antibody responses during primary and secondary infections with respiratory syncytial virus
    Scott, Paul D.
    Ochola, Rachel
    Sande, Charles
    Ngama, Mwanajuma
    Okiro, Emelda A.
    Medley, Graham F.
    Nokes, D. James
    Cane, Patricia A.
    JOURNAL OF MEDICAL VIROLOGY, 2007, 79 (12) : 1943 - 1950
  • [26] Serum antibody decay in adults following natural respiratory syncytial virus infection
    Falsey, Ann R.
    Singh, Harjot K.
    Walsh, Edward E.
    JOURNAL OF MEDICAL VIROLOGY, 2006, 78 (11) : 1493 - 1497
  • [27] Respiratory syncytial virus and human metapneumovirus in children with acute respiratory infections in Yemen
    Al-Sonboli, N
    Hart, CA
    Al-Aeryani, A
    Banajeh, SM
    Al-Aghbari, N
    Dove, W
    Cuevas, LE
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2005, 24 (08) : 734 - 736
  • [28] Respiratory syncytial virus - associated lower respiratory tract infections in hospitalized infants
    D'Elia, C
    Siqueira, MM
    Portes, SA
    Sant'Anna, CC
    REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 2005, 38 (01) : 7 - 10
  • [29] Outpatient respiratory syncytial virus infections and novel preventive interventions
    Hak, Sarah F.
    Venekamp, Roderick P.
    Wildenbeest, Joanne G.
    Bont, Louis J.
    CURRENT OPINION IN PEDIATRICS, 2024, 36 (02) : 171 - 181
  • [30] Epidemiology and prevention of respiratory syncytial virus infections in children in Italy
    Chiara Azzari
    Eugenio Baraldi
    Paolo Bonanni
    Elena Bozzola
    Alessandra Coscia
    Marcello Lanari
    Paolo Manzoni
    Teresa Mazzone
    Fabrizio Sandri
    Giovanni Checcucci Lisi
    Salvatore Parisi
    Giorgio Piacentini
    Fabio Mosca
    Italian Journal of Pediatrics, 47
12345