Current status and prospects of nanosuspension for improved transdermal targeted drug delivery

As a non-invasive dosage form, transdermal targeted drug delivery system avoids first-pass effect, improves and maintains blood drug concentration, reduces gastrointestinal stimulation, eliminates adverse reactions, and increases patient compliance. However, due to the barrier function of the stratum corneum of the skin, only a few drugs are suitable for transdermal administration, and most drugs cannot reach effective therapeutic concentrations through the skin after transdermal administration. The key to solve the problem is to improve the drugs transdermal permeability and prolong the retention time. The main advantages of nanosuspension are including high drug loading, small particle size, large specific surface area, easy industrial production. Therefore, the nanosuspension for transdermal target delivery has strong adhesion and penetration with skin, is not easy to be removed, and significantly improves the pharmacokinetic characteristics and bioavailability of water insoluble drugs. The influencing factors for transdermal delivery, nanosuspension technology for improving the skin penetration, as well as challenges and future perspectives was reviewed in this article. Nanosuspension can promote the transdermal target absorption of drugs and improve the bioavailability of local drug delivery, which present a good clinical application prospect. This review could be provide a reference for the nanosuspension technology in the transdermal target drug delivery.