Differential roles of Alzheimer's disease plasma biomarkers in stepwise biomarker-guided diagnostics

被引：0

作者：

Jang, Hyemin ^{[1
]}

Shin, Daeun ^{[2
]}

Yoo, Heejin ^{[2
]}

Zetterberg, Henrik ^{[3
,4
,5
,6
,7
,8
]}

Blennow, Kaj ^{[3
,4
,9
,10
,11
,12
]}

Gonzalez-Ortiz, Fernando ^{[3
,4
]}

Ashton, Nicholas J. ^{[3
,13
,14
,15
,16
]}

Day, Theresa A. ^{[17
]}

Lee, Eun Hye ^{[2
]}

Yun, Jihwan ^{[18
]}

Na, Duk L. ^{[2
]}

Kim, Hee Jin ^{[2
,19
,20
,21
]}

Kang, Sung Hoon ^{[22
]}

Kim, Ko Woon ^{[23
]}

Kim, Si Eun ^{[24
]}

Kim, Yeo Jin ^{[25
]}

Kim, Yeshin ^{[26
]}

Kim, Jaeho ^{[27
]}

Kim, Chi-Hun ^{[28
]}

Chun, Min Young ^{[29
,30
]}

Jung, Na Yeon ^{[31
]}

Cho, Soo Hyun ^{[32
]}

Kim, Jun Pyo ^{[2
]}

Seo, Sang Won ^{[2
,19
,20
,21
]}

K-ROAD Study Grp

机构：

[1] Seoul Natl Univ, Coll Med, Dept Neurol, Seoul Natl Univ Hosp, Seoul, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, 81 Irwon Ro, Seoul 06351, South Korea

[3] Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden

[4] Sahlgrens Univ Hosp, Clin Neurochem Lab, Gothenburg, Sweden

[5] UCL, Dept Neurodegenerat Dis, Inst Neurol, Queen Sq, London, England

[6] UCL, UK Dementia Res Inst, London, England

[7] Hong Kong Ctr Neurodegenerat Dis, Clear Water Bay, Hong Kong, Peoples R China

[8] Univ Wisconsin Madison, Wisconsin Alzheimers Dis Res Ctr, Univ Wisconsin Sch Med & Publ Hlth, Madison, WI USA

[9] Sorbonne Univ, Pitie Salpetriere Hosp, Paris Brain Inst, ICM, Paris, France

[10] Univ Sci & Technol China, Affiliated Hosp USTC 1, Inst Aging & Brain Disorders, Hefei, Peoples R China

[11] Univ Sci & Technol China, Inst Aging & Brain Disorders, Dept Neurol, Hefei, Peoples R China

[12] USTC, Affiliated Hosp 1, Hefei, Peoples R China

[13] Kings Coll London, Maurice Wohl Clin Neurosci Inst, Inst Psychiat Psychol & Neurosci, De Crespigny Pk, London, England

[14] South London & Maudsley NHS Fdn Trust, NIHR Biomed Res Ctr Mental Hlth, De Crespigny Pk, London, England

[15] South London & Maudsley NHS Fdn, Biomed Res Unit Dementia, De Crespigny Pk, London, England

[16] Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway

[17] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN USA

[18] Soonchunhyang Univ, Bucheon Hosp, Dept Neurol, Bucheon Si, Gyeonggi Do, South Korea

[19] Samsung Med Ctr, Alzheimers Dis Convergence Res Ctr, Seoul, South Korea

[20] Sungkyunkwan Univ, Dept Hlth Sci & Technol, SAIHST, Seoul, South Korea

[21] Samsung Med Ctr, Neurosci Ctr, Seoul, South Korea

[22] Korea Univ, Coll Med, Dept Neurol, Guro Hosp, Seoul, South Korea

[23] Jeonbuk Natl Univ, Med Sch & Hosp, Dept Neurol, Jeonju Si, South Korea

[24] Inje Univ, Coll Med, Haeundae Paik Hosp, Dept Neurol, Busan, South Korea

[25] Hallym Univ, Coll Med, Kangdong Sacred Heart Hosp, Dept Neurol, Seoul, South Korea

[26] Kangwon Natl Univ, Sch Med, Kangwon Natl Univ Hosp, Dept Neurol, Chuncheon Si, Gangwon Do, South Korea

[27] Hallym Univ, Coll Med, Dongtan Sacred Heart Hosp, Dept Neurol, Seoul, South Korea

[28] Hallym Univ, Coll Med, Dept Neurol, Sacred Heart Hosp, Anyang Si 431070, Gyeonggi Do, South Korea

[29] Yonsei Univ, Coll Med, Dept Neurol, Seoul, South Korea

[30] Yonsei Univ Hlth Syst, Yongin Severance Hosp, Dept Neurol, Yongin, Gyeonggi Do, South Korea

[31] Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Dept Neurol, Yangsan Si, Gyeongsangnam D, South Korea

[32] Chonnam Natl Univ, Chonnam Natl Univ Hosp, Med Sch, Dept Neurol, Gwangju, South Korea

来源：

ALZHEIMERS & DEMENTIA | 2025年 / 21卷 / 02期

基金：

瑞典研究理事会; 新加坡国家研究基金会;

关键词：

Alzheimer's disease; neurofilament light chain; positron emission tomography; plasma biomarker; p-tau217; PHOSPHORYLATED TAU 181; NEUROFILAMENT LIGHT; BLOOD BIOMARKERS; PROTEIN;

D O I：

10.1002/alz.14526

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION This study aimed to investigate the differential roles of various plasma biomarkers in a stepwise diagnostic strategy for Alzheimer's disease (AD). METHODS A total of 2984 participants, including 666 cognitively unimpaired (CU), 2032 with Alzheimer's clinical syndrome (ACS), and 286 non-ACS individuals, were recruited. Plasma amyloid beta (A beta) 42/40, four phosphorylated tau (p-tau) epitopes, glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) levels were measured using immunoassays. RESULTS NfL demonstrated fair to excellent accuracy in differentiating non-ACS from CU groups (area under the curve [AUC], 0.79 to 0.94). p-tau217 had the highest accuracy for identifying A beta (AUC 0.94) and tau positron emission tomography status (AUC 0.91). In the ACS group, p-tau217 was the strongest predictor of cognitive decline (p < .001). DISCUSSION NfL may serve as a useful screening tool, while p-tau217 is particularly valuable for confirming AD pathology and prognosis.

引用

页数：12

共 50 条

[41] Plasma Neurofilament Light and Alzheimer's Disease Biomarkers in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)
Raffi, Michael S.
Donohue, Michael C.
Matthews, Dawn C.
Muranevici, Gabriela
Ness, Seth
O'Bryant, Sid E.
Rissman, Robert A.
[J]. JOURNAL OF ALZHEIMERS DISEASE, 2019, 70 (01) : 131 - 138
[42] Plasma Amyloid-β as a Biomarker in Alzheimer's Disease: The AIBL Study of Aging
Lui, James K.
Laws, Simon M.
Li, Qiao-Xin
Villemagne, Victor L.
Ames, David
Brown, Belinda
Bush, Ashley I.
De Ruyck, Karl
Dromey, Jasmin
Ellis, Kathryn A.
Faux, Noel G.
Foster, Jonathan
Fowler, Christopher
Gupta, Veer
Hudson, Peter
Laughton, Katrina
Masters, Colin L.
Pertile, Kelly
Rembach, Alan
Rimajova, Mira
Rodrigues, Mark
Rowe, Christopher C.
Rumble, Rebecca
Szoeke, Cassandra
Taddei, Kevin
Taddei, Tania
Trounson, Brett
Ward, Vanessa
Martins, Ralph N.
[J]. JOURNAL OF ALZHEIMERS DISEASE, 2010, 20 (04) : 1233 - 1242
[43] Plasma amyloid-β oligomers level is a biomarker for Alzheimer's disease diagnosis
Zhou, L.
Chan, K. H.
Chu, L. W.
Kwan, J. S. C.
Song, Y. Q.
Chen, L. H.
Ho, P. W. L.
Cheng, O. Y.
Ho, J. W. M.
Lam, K. S. L.
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 423 (04) : 697 - 702
[44] Potential Roles of α-amylase in Alzheimer's Disease: Biomarker and Drug Target
Chen, Win Ning
Tang, Kim San
Yeong, Keng Yoon
[J]. CURRENT NEUROPHARMACOLOGY, 2022, 20 (08) : 1554 - 1563
[45] Blood Biomarkers for Alzheimer's Disease in Down Syndrome
Montoliu-Gaya, Laia
Strydom, Andre
Blennow, Kaj
Zetterberg, Henrik
Ashton, Nicholas James
[J]. JOURNAL OF CLINICAL MEDICINE, 2021, 10 (16)
[46] Blood-based biomarkers in Alzheimer's disease - moving towards a new era of diagnostics
Arslan, Burak
Zetterberg, Henrik
Ashton, Nicholas J.
[J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2024, 62 (06) : 1063 - 1069
[47] Plasma Hepcidin as a potential informative biomarker of Alzheimer disease and vascular dementia
Delaby, Constance
Alcolea, Daniel
Busto, Germain
Gabelle, Audrey
Ayrignac, Xavier
Bennys, Karim
Muino, Elena
Villatoro, Paula
Fernandez-Cadenas, Israel
Pradeilles, Nicolas
El Bounasri, Shaima
Torres, Soraya
Hirtz, Christophe
Zetterberg, Henrik
Lleo, Alberto
Fortea, Juan
Lehmann, Sylvain
[J]. ALZHEIMERS RESEARCH & THERAPY, 2025, 17 (01)
[48] Differential roles of regulatory T cells in Alzheimer's disease
Jafarzadeh, Abdollah
Sheikhi, Abdolkarim
Jafarzadeh, Zahra
Nemati, Maryam
[J]. CELLULAR IMMUNOLOGY, 2023, 393
[49] Plasma biomarkers for diagnosis and differentiation and their cognitive correlations in patients with Alzheimer's disease
Sun, Wenhao
Ye, Shuwei
Wang, Yu
Chen, Huifeng
Che, Ping
Chen, Jingshan
Zhang, Nan
[J]. BRAIN COMMUNICATIONS, 2025, 7 (02)
[50] Combination of plasma biomarkers and clinical data for the detection of sporadic Alzheimer's disease
Han, Yangtong
Jia, Jianping
Jia, Xiang-Fei
Qin, Wei
Wang, Suying
[J]. NEUROSCIENCE LETTERS, 2012, 516 (02) : 232 - 236

← 1 2 3 4 5 →