This study analyzes the effect of emotional self-efficacy, irritability and aggressiveness on empathy in vulnerable adolescents. Quantitative, non-experimental- cross-sectional study and correlational scope. We worked with 69 adolescents to whom the Interpersonal Reactivity Index and the Self-Efficacy Scales for Emotional Regulation, Irritability and Physical and Verbal Aggressiveness were applied. Empathy correlated directly with emotional self-efficacy and inversely with irritability and physical and verbal aggressiveness. Path analysis showed that emotional self-efficacy, irritability, physical and verbal aggressiveness provided a predictive effect on perspective taking, concern, empathy, and emotional distress.