TRPA1 and thermosensitivity

被引：0
作者：
Tominaga, Makoto [1 ]
Iwata, Moe [1 ]
机构：
[1] Nagoya City Univ, Nagoya Adv Res & Dev Ctr, Thermal Biol Res Grp, Kawasumi 1,Mizuho Cho,Mizuho Ku, Nagoya 4678601, Japan
来源：
JOURNAL OF PHYSIOLOGICAL SCIENCES | 2025年 / 75卷 / 01期
关键词：
TRPA1; Temperature; Thermosensitivity; Ion channels; Cold; Heat; POTENTIAL ANKYRIN 1; ION-CHANNEL TRPA1; DICTATE SENSITIVITY; CAPSAICIN RECEPTOR; HEAT; COLD; THERMOSENSATION; A1; ACTIVATION; UNDERLIES;
D O I：
10.1016/j.jphyss.2025.100010
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
TRPA1 was first identified as a noxious cold receptor in mice in 2003. Multiple TRPA1 genes have since been isolated, indicating that TRPA1 emerged early in evolution and showing the existence of TRPA1 variants in a range of species, including insects. Although TRPA1 channels in insects to birds (endotherms) show heat-dependent activation that indicates the importance of TRPA1 for detecting ambient warm to hot temperatures, in mammals TRPA1 temperature sensitivity remains controversial. Analyses of insect TRPA1 highlighted several important structural motifs, but the structural basis of heat-evoked activation is still unclear. Furthermore, atomic-level structures of TRPA1 solved using single particle analysis with cryo-electron microscopy did not reveal a basis for TRPA1 thermosensitivity. Recent studies did demonstrate that human TRPA1 has bimodal thermosensitivity and mouse TRPA1 is involved in noxious heat sensitivity, but additional systematic analyses are needed to determine the general mechanism of mammalian TRPA1 thermosensitivity.
引用
收藏
页数：6
相关论文
共 60 条
  • [1] Laursen W.J., Anderson E.O., Hoffstaetter L.J., Bagriantsev S.N., Gracheva E.O., Species-specific temperature sensitivity of TRPA1, Temp. (Austin), 2, pp. 214-226, (2015)
  • [2] Talavera K., Startek J.B., Alvarez-Collazo J., Boonen B., Alpizar Y.A., Sanchez A., Naert R., Nilius B., Mammalian transient receptor potential trpa1 channels: from structure to disease, Physiol. Rev., 100, pp. 725-803, (2020)
  • [3] Jaquemar D., Schenker T., Trueb B., An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts, J. Biol. Chem., 274, pp. 7325-7333, (1999)
  • [4] Story G.M., Peier A.M., Reeve A.J., Eid S.R., Mosbacher J., Hricik T.R., Earley T.J., Hergarden A.C., Andersson D.A., Hwang S.W., McIntyre P., Jegla T., Bevan S., Patapoutian A., ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures, Cell, 112, pp. 819-829, (2003)
  • [5] Karashima Y., Damann N., Prenen J., Talavera K., Segal A., Voets T., Nilius B., Bimodal action of menthol on the transient receptor potential channel TRPA1, J. Neurosci., 27, pp. 9874-9884, (2007)
  • [6] Bandell M., Story G.M., Hwang S.W., Viswanath V., Eid S.R., Petrus M.J., Earley T.J., Patapoutian A., Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin, Neuron, 41, pp. 849-857, (2004)
  • [7] Jordt S.E., Bautista D.M., Chuang H.H., McKemy D.D., Zygmunt P.M., Hogestatt E.D., Meng I.D., Julius D., Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1, Nature, 427, pp. 260-265, (2004)
  • [8] Kwan K.Y., Allchorne A.J., Vollrath M.A., Christensen A.P., Zhang D.S., Woolf C.J., Corey D.P., TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction, Neuron, 50, pp. 277-289, (2006)
  • [9] Bautista D.M., Jordt S.E., Nikai T., Tsuruda P.R., Read A.J., Poblete J., Yamoah E.N., Basbaum A.I., Julius D., TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents, Cell, 124, pp. 1269-1282, (2006)
  • [10] Caterina M.J., Schumacher M.A., Tominaga M., Rosen T.A., Levine J.D., Julius D., The capsaicin receptor: a heat-activated ion channel in the pain pathway, Nature, 389, pp. 816-824, (1997)
123456