Alterations of renal polyamine metabolism in mice with folic acid-induced chronic kidney disease

被引：0
作者：
Xue, Cheng [1 ]
Chen, Jiaxin [1 ]
Li, Xinming [1 ]
Zhou, Chenchen [1 ,2 ]
Mao, Zhiguo [1 ]
机构：
[1] Second Mil Med Univ, Naval Med Univ, Shanghai Changzheng Hosp, Div Nephrol, Shanghai, Peoples R China
[2] Yangpu Third Mil Retreat, Outpatient Dept, Shanghai 200000, Peoples R China
来源：
BIOCHEMISTRY AND BIOPHYSICS REPORTS | 2025年 / 42卷
关键词：
Mass spectrometry imaging; Metabolomic; Chronic kidney disease; SPERMIDINE;
D O I：
10.1016/j.bbrep.2025.101967
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chronic kidney disease (CKD) often follows acute kidney injury, leading to renal fibrosis and progressive renal failure. Spermine, a polyamine with antioxidant and anti-inflammatory properties, helps reduce renal fibrosis and may serve as a biomarker for CKD progression. We used spatially resolved metabonomic analysis with AFADESI-MSI to examine polyamine distribution in kidneys of a folic acid (FA)-induced CKD mouse model. Results showed decreased spermine and increased spermidine levels, associated with elevated spermine oxidase (SMOX) and spermidine/spermine N1-acetyltransferase (SSAT) enzyme expression in CKD. These findings suggest that altered polyamine metabolism contributes to CKD progression and may provide targets for polyaminebased therapies.
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