Grafting a chromophore on AMD070 analogues for CXCR4 bioimaging: Chemical synthesis and in vitro assessment of the inhibition properties of the CXCR4 receptor

被引：0

作者：

Roy, Marie M. Le ^{[1
]}

Metivier, Cassandra

Le Saec, Patricia

Bouhsine, Hela ^{[2
]}

Cherel, Michel ^{[2
]}

Faivre-Chauvet, Alain ^{[2
]}

Troadec, Thibault ^{[1
]}

Tripier, Raphael ^{[1
]}

机构：

[1] Univ Brest, UMR CNRS CEMCA 6521, 6 Ave Victor Le Gorgeu, F-29200 Brest, France

[2] Univ Angers, Nantes Univ, Inserm UMR 1307, CNRS UMR 6075, CRCI 2,8 Quai Moncousu, F-44007 Nantes, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2025年 / 115卷

关键词：

CXCR4; AMD070; Fluorescence; HUMAN-IMMUNODEFICIENCY-VIRUS; SELECTIVE-INHIBITION; CHEMOKINE; BICYCLAM; ANTAGONISTS; EXPRESSION; POTENT; CORECEPTOR; PET/CT; ENTRY;

D O I：

10.1016/j.bmcl.2024.130027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thank to their particular pharmacokinetics, the use of small organic molecules can be a very promising alternative to macromolecular targeting biomolecules (i.e. antibodies, peptides...) for specific imaging of tumours. Herein, the potential of two AMD070-like inhibitors as CXCR4-targeting units for specific imaging of cancer cells, and the influence of chromophore-grafting on their recognition properties was investigated.

引用

页数：5

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