Transition-metal-free decarbonylation-oxidation of 3-arylbenzofuran-2(3H)-ones: access to 2-hydroxybenzophenones

被引：0
|
作者：
Dhotare, Bhaskar B. [1 ]
V. Kanojia, Seema [1 ]
Sakhiya, Chahna K. [2 ]
Wadawale, Amey [3 ]
Goswami, Dibakar [1 ,4 ]
机构：
[1] Bhabha Atom Res Ctr, Bioorgan Div, Trombay 400085, Mumbai, India
[2] NMIMS Sunandan Divatia Sch Sci, Vile Parle, Mumbai 400056, India
[3] Bhabha Atom Res Ctr, Chem Div, Mumbai 400085, India
[4] Homi Bhabha Natl Inst, Anushaktinagar, Mumbai 400094, India
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 20卷
关键词：
decarbonylation-oxidation; hydroperoxide; 2-hydroxybenzophenone; transition-metal-free; UV-protection; REARRANGEMENT; MECHANISM;
D O I：
10.3762/bjoc.20.223
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A transition-metal-free decarbonylation-oxidation protocol for the conversion of 3-arylbenzofuran-2(3H)-ones H )-ones to 2-hydroxybenzophenones under mild conditions has been developed. NMR studies confirmed the role of in-situ-generated hydroperoxide in the conversion. The protocol was applied to a diverse range of substrates to access the target products in good to excellent yields. A structure-activity study for the 5-substituted-2-hydroxybenzophenones towards UV-protection abilities has been verified by mathematical calculations.
引用
收藏
页码：2655 / 2667
页数：13
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