Transition-metal-free decarbonylation-oxidation of 3-arylbenzofuran-2(3H)-ones: access to 2-hydroxybenzophenones

被引：0

作者：

Dhotare, Bhaskar B. ^{[1
]}

V. Kanojia, Seema ^{[1
]}

Sakhiya, Chahna K. ^{[2
]}

Wadawale, Amey ^{[3
]}

Goswami, Dibakar ^{[1
,4
]}

机构：

[1] Bhabha Atom Res Ctr, Bioorgan Div, Trombay 400085, Mumbai, India

[2] NMIMS Sunandan Divatia Sch Sci, Vile Parle, Mumbai 400056, India

[3] Bhabha Atom Res Ctr, Chem Div, Mumbai 400085, India

[4] Homi Bhabha Natl Inst, Anushaktinagar, Mumbai 400094, India

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 20卷

关键词：

decarbonylation-oxidation; hydroperoxide; 2-hydroxybenzophenone; transition-metal-free; UV-protection; REARRANGEMENT; MECHANISM;

D O I：

10.3762/bjoc.20.223

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A transition-metal-free decarbonylation-oxidation protocol for the conversion of 3-arylbenzofuran-2(3H)-ones H )-ones to 2-hydroxybenzophenones under mild conditions has been developed. NMR studies confirmed the role of in-situ-generated hydroperoxide in the conversion. The protocol was applied to a diverse range of substrates to access the target products in good to excellent yields. A structure-activity study for the 5-substituted-2-hydroxybenzophenones towards UV-protection abilities has been verified by mathematical calculations.

引用

页码：2655 / 2667

页数：13

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